The molecular mechanism of nuclear signaling for degradation of cytoplasmic DNA: Importance in DNA damage response and cancer

DNA Repair ◽  
2021 ◽  
Vol 103 ◽  
pp. 103115
Author(s):  
Erfan Mohammadi ◽  
Fatemeh Sadoughi ◽  
Simin Younesi ◽  
Ansar Karimian ◽  
Zatollah Asemi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Molecular Mechanism ◽  
Dna Damage Response ◽  
Nuclear Signaling ◽  
Cytoplasmic Dna ◽  
Damage Response

scholarly journals Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2892
Author(s):  
Kexiong Zhang ◽  
Lihui Wang ◽  
Xiaojing Hong ◽  
Hao Chen ◽  
Yao Shi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Stem Cell ◽  
Molecular Mechanism ◽  
Dna Damage Response ◽  
Replicative Senescence ◽  
Low Grade ◽  
Natural Ageing ◽  
Premature Ageing ◽  
Damage Response ◽  
Late Generation

Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that naturally occurring ageing is associated with the DNA damage response (DDR) and activation of the p53 signalling pathway. Telomerase deficiency induced by telomerase RNA component (TERC) knockout (KO) accelerates not only replicative senescence but also altered differentiation and apoptosis of the pulmonary alveolar stem cells (AEC2) in association with increased innate immune natural killer (NK) cells in TERC KO mice. TERC KO results in increased senescence-associated heterochromatin foci (SAHF) marker HP1γ, p21, p16, and apoptosis-associated cleaved caspase-3 in AEC2. However, additional deficiency of the tumour suppressor p53 in the Trp53−/− allele of the late generation of TERC KO mice attenuates the increased senescent and apoptotic markers significantly. Moreover, p53 deficiency has no significant effect on the increased gene expression of T1α (a marker of terminal differentiated AEC1) in AEC2 of the late generation of TERC KO mice. These findings demonstrate that, in natural ageing or premature ageing accelerated by telomere shortening, pulmonary senescence and IPF develop with alveolar stem cell p53-dependent premature replicative senescence, apoptosis, and p53-independent differentiation, resulting in pulmonary senescence-associated low-grade inflammation (SALI). Our studies indicate a natural ageing-associated molecular mechanism of telomerase deficiency-induced telomere DDR and SALI in pulmonary ageing and IPF.

Abstract 5202: Molecular mechanism of transcriptional regulation ofREV7, a DNA damage response gene

2019 ◽  
Author(s):  
Yoshiki Murakumo ◽  
Yuko Shimada ◽  
Takuya Kato ◽  
Yasutaka Sakurai
Keyword(s):  
Dna Damage ◽  
Transcriptional Regulation ◽  
Molecular Mechanism ◽  
Dna Damage Response ◽  
Response Gene ◽  
Damage Response

Abstract 5202: Molecular mechanism of transcriptional regulation ofREV7, a DNA damage response gene

2019 ◽  
Author(s):  
Yoshiki Murakumo ◽  
Yuko Shimada ◽  
Takuya Kato ◽  
Yasutaka Sakurai
Keyword(s):  
Dna Damage ◽  
Transcriptional Regulation ◽  
Molecular Mechanism ◽  
Dna Damage Response ◽  
Response Gene ◽  
Damage Response

scholarly journals Autophagy as the effector and player in DNA damage response of cells to genotoxicants

2015 ◽  
Vol 4 (3) ◽  
pp. 613-622 ◽  
Author(s):  
Shi-Meng Zhang ◽  
Zeng-Fu Shang ◽  
Ping-Kun Zhou
Keyword(s):  
Dna Damage ◽  
Molecular Mechanism ◽  
Cell Fate ◽  
Dna Damage Response ◽  
Environmental Toxicants ◽  
Cell Fate Determination ◽  
Genotoxic Effects ◽  
Fate Determination ◽  
Damage Response ◽  
Mutual Regulation

In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response
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