Cognitive Training in Recently-Abstinent Individuals with Alcohol Use Disorder Improves Emotional Stroop Performance: Evidence from a Randomized Pilot Trial

2021 ◽  
pp. 109239
Author(s):  
Ben Lewis ◽  
Christian C. Garcia ◽  
Julianne L. Price ◽  
Susanne Schweizer ◽  
Sara Jo Nixon
Keyword(s):  
Alcohol Use ◽  
Cognitive Training ◽  
Alcohol Use Disorder ◽  
Pilot Trial ◽  
Emotional Stroop

scholarly journals Topiramate Treatment of Alcohol Use Disorder in Veterans with Posttraumatic Stress Disorder: A Randomized Controlled Pilot Trial

2014 ◽  
Vol 38 (8) ◽  
pp. 2169-2177 ◽  
Author(s):  
Steven L. Batki ◽  
David L. Pennington ◽  
Brooke Lasher ◽  
Thomas C. Neylan ◽  
Thomas Metzler ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Alcohol Use ◽  
Posttraumatic Stress ◽  
Alcohol Use Disorder ◽  
Stress Disorder ◽  
Pilot Trial ◽  
Randomized Controlled

scholarly journals Melatonin for Treatment-Seeking Alcohol Use Disorder patients with sleeping problems: A randomized clinical pilot trial

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marie N. S. Gendy ◽  
Dina Lagzdins ◽  
Jessika Schaman ◽  
Bernard Le Foll
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Pilot Trial ◽  
Complex Problem ◽  
Treatment Seeking ◽  
Future Research ◽  
Treatment Change ◽  
Sleeping Problems ◽  
Before And After ◽  
The Difference

Abstract A high percentage of subjects diagnosed with alcohol use disorder (AUD) suffer from sleeping difficulties. Lack of sleep could lead AUD patients to relapse or, sometimes, to suicide. Most of the currently prescribed medications to treat this complex problem retain a high risk of side effects and/or dependence. Therefore, the aim of the current clinical trial is to investigate the possibility of the use of a safer treatment, such as the natural health product melatonin, to treat alcohol-related sleeping problems. Sixty treatment-seeking AUD subjects were assigned to melatonin (5 mg) or placebo for 4 weeks of treatment. Change in sleeping quality which is the primary outcome of the study was assessed using the Pittsburgh sleep quality index (PSQI) scale. Linear mixed models were used to statistically analyze the difference in scores before and after 4 weeks of treatment. There was a reduction in the global PSQI score in both groups with no significant drug effect between groups. In conclusion, the use of melatonin (5 mg)/day didn’t differ from placebo in decreasing sleeping problems in a sample of AUD subjects after 4 weeks of treatment. However, higher doses are worth exploring in future research.

scholarly journals Pilot trial investigating a brief behavioral economic intervention as an adjunctive treatment for alcohol use disorder

2020 ◽  
Vol 113 ◽  
pp. 108002 ◽  
Author(s):  
Lidia Z. Meshesha ◽  
Kathryn E. Soltis ◽  
Edward A. Wise ◽  
Damaris J. Rohsenow ◽  
Katie Witkiewitz ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Pilot Trial ◽  
Adjunctive Treatment ◽  
Behavioral Economic

scholarly journals Virtual Reality Cognitive Training in Individuals with Alcohol Use Disorder Undergoing Residential Treatment: A Pilot Randomized Controlled Trial (Preprint)

2020 ◽  
Author(s):  
Pedro Gamito ◽  
Jorge Oliveira ◽  
Marcelo Matias ◽  
Elsa Cunha ◽  
Rodrigo Brito ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Alcohol Use ◽  
Cognitive Training ◽  
Cognitive Flexibility ◽  
Alcohol Use Disorder ◽  
Controlled Trial ◽  
Treatment As Usual ◽  
Randomized Controlled ◽  
Global Cognition ◽  
Pilot Randomized Controlled Trial

BACKGROUND Alcohol use disorder has been associated with diverse physical and mental morbidities. Among the main consequences of chronic and excessive alcohol use are cognitive and executive deficits. Some of these deficits may be reversed in specific cognitive and executive domains with behavioral approaches consisting in cognitive training. The advent of computer-based interventions may leverage these improvements, but RCTs of digital interactive-based interventions are still scarce. OBJECTIVE The aim is to explore whether a cognitive training approach using virtual reality exercises based on activities of daily living is feasible for improving cognitive function of patients with alcohol use disorder undergoing residential treatment, as well as to estimate the effect size for this intervention to power future definitive RCTs. METHODS A two-arm pilot randomized controlled trial with a sample of 36 individuals recovering from alcohol use disorder in a therapeutic community assigned to a therapist-guided virtual reality-based cognitive training combined with treatment-as-usual or a control group with treatment-as-usual without cognitive training. A comprehensive neuropsychological battery of tests was used both at pre and post assessments, including global cognition, executive functions, attention, visual memory and cognitive flexibility. RESULTS In order to control for potential effects of global cognition and executive functions at baseline, these domains were controlled in the statistical analysis for each individual outcome. Results indicate effects (P < .05) of the intervention on attention (in 2 out of 5 outcomes) and cognitive flexibility (in 2 out of 6 outcomes), with effect sizes in significant comparisons being larger for attention than for cognitive flexibility. Patient retention in cognitive training was high, in line with previous studies. CONCLUSIONS Overall data suggest specific contributions of reality-based cognitive training in improving attention ability and cognitive flexibility of patients recovering from alcohol use disorder. CLINICALTRIAL ClinicalTrials.gov NCT04505345; https://clinicaltrials.gov/show/NCT04505345

Randomized controlled pilot trial of supportive text messaging for alcohol use disorder patients

2018 ◽  
Vol 94 ◽  
pp. 74-80 ◽  
Author(s):  
Vincent I.O. Agyapong ◽  
Michal Juhás ◽  
Kelly Mrklas ◽  
Marianne Hrabok ◽  
Joy Omeje ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Text Messaging ◽  
Alcohol Use Disorder ◽  
Pilot Trial ◽  
Randomized Controlled
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