Monitoring the ecotoxicity of γ-Al2O3 and Ni/γ-Al2O3 nanomaterials by means of a battery of bioassays

2017 ◽  
Vol 144 ◽  
pp. 200-207 ◽  
Author(s):  
Gabriela Svartz ◽  
Mariana Papa ◽  
Marina Gosatti ◽  
Marianela Jordán ◽  
Analia Soldati ◽  
...  
Keyword(s):  
Battery Of Bioassays

Assessing changes in the toxicity of effluents from intensive marine fish farms over time by using a battery of bioassays

2018 ◽  
Vol 25 (13) ◽  
pp. 12739-12748 ◽  
Author(s):  
Carlos Carballeira ◽  
Alesandra Cebro ◽  
Rubén Villares ◽  
Alejo Carballeira
Keyword(s):  
Marine Fish ◽  
Fish Farms ◽  
Over Time ◽  
Battery Of Bioassays

scholarly journals Microscale ecotoxicity testing of Moselle river watershed (Lorraine Province, France) sediments

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jean François Férard ◽  
Karen F. Burga Pérez ◽  
Christian Blaise ◽  
Alexandre Péry ◽  
Pakawadee Sutthivaiyakit ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Sublethal Effects ◽  
Solid Phase ◽  
Ecotoxicity Test ◽  
River Watershed ◽  
Ecotoxicity Testing ◽  
Sediment Particles ◽  
Secondary Consumers ◽  
Solid Phase Assay ◽  
Battery Of Bioassays

The ecotoxic potential of seven Moselle river watershed sediments was assessed with a battery of bioassays comprised of rapid phototrophic [LuminoTox solid phase (L-SPA) and elutriate (L-ELU) assays] and bacterial [Microtox solid phase assay (M-SPA)] exposure tests, as well as with two micro-invertebrate solid phase tests conducted with <em>Hydra</em> <em>attenuata</em> (lethal and sublethal effects solid phase assay, H<sub>L</sub>-SPA and H<sub>SL</sub>-SPA) and <em>Chironomus</em> <em>riparius</em>. Measured effects of sediments and their elutriates were varied and reflected responses that were ecotoxicity test-, endpoint- and site-dependent, suggesting some degree of risk toward benthic and water column organisms, respectively, at specific sites. Correlation analysis demonstrated that L-SPA and M-SPA ecotoxicity responses were significantly linked with the Hydra H<sub>SL</sub>-SPA assay, indicating their ability to predict ecotoxicity towards an invertebrate taxonomic group representing secondary consumers. While the L-SPA and M-SPA assays hold promise as rapid screens for sediment ecotoxicity, correlation analysis with grain size (L-SPA: r=-0.795, P=0.033; M-SPA: r=-0.73, P=0.07) points out that their responses can be influenced by the presence of fines (<em>i.e</em>., sediment particles ≤0.063 mm in size) and that this information is essential to properly interpret ecotoxicity data generated with these assays. Finally, notable differences observed in trophic level sensitivities once again recall the importance of employing a test battery to adequately appraise the ecotoxicity of sediments.

scholarly journals Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice

2017 ◽  
Vol 11 ◽  
pp. 117822181770173 ◽  
Author(s):  
Timothy W Lefever ◽  
Julie A Marusich ◽  
Brian F Thomas ◽  
Daniel G Barrus ◽  
Nicholas C Peiper ◽  
...  
Keyword(s):  
Time Course ◽  
Synthetic Cannabinoids ◽  
Route Of Administration ◽  
Preclinical Model ◽  
Cigarette Use ◽  
Duration Of Action ◽  
Aerosol Exposure ◽  
Full Profile ◽  
Cp 55,940 ◽  
Battery Of Bioassays

Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids (“fake marijuana”) in electronic cigarette devices has become increasingly popular. Yet, most animal models used to investigate biological mechanisms underlying cannabis use employ injection as the route of administration. This study evaluated a novel e-cigarette device that delivers aerosolized cannabinoids to mice. The effects of aerosolized and injected synthetic cannabinoids (CP 55,940, AB-CHMINACA, XLR-11, and JWH-018) in mice were compared in a battery of bioassays in which psychoactive cannabinoids produce characteristic effects. The most potent cannabinoids (CP 55,940 and AB-CHMINACA) produced the full cannabinoid profile (ie, hypothermia, hypolocomotion, and analgesia), regardless of the route of administration. In contrast, aerosolized JWH-018 and XLR-11 did not produce the full profile of cannabimimetic effects. Results of time course analysis for hypothermia showed that aerosol exposure to CP 55,940 and AB-CHMINACA produced faster onset of effects and shorter duration of action than injection. The ability to administer cannabinoids to rodents using the most common route of administration among humans provides a method for collecting preclinical data with enhanced translational relevance.

scholarly journals Synthesis and ecotoxicological impact of ferrocene-derived amino-phosphonates using a battery of bioassays

RSC Advances ◽  
2017 ◽  
Vol 7 (61) ◽  
pp. 38399-38409 ◽  
Author(s):  
J. Lewkowski ◽  
R. Karpowicz ◽  
M. Morawska ◽  
P. Rychter ◽  
D. Rogacz ◽  
...  
Keyword(s):  
Marine Bacteria ◽  
Higher Plants ◽  
Amino Phosphonates ◽  
Freshwater Ostracods ◽  
Battery Of Bioassays

Ferrocene-derived aminophosphonates showed their various ecotoxicological impact on terrestrial higher plants, freshwater ostracods and marine bacteria.

Effectiveness of ozonation and chlorination on municipal wastewater treatment evaluated by a battery of bioassays and biomarkers

2009 ◽  
Vol 60 (6) ◽  
pp. 1497-1505 ◽  
Author(s):  
A. Kontana ◽  
C. A. Papadimitriou ◽  
P. Samaras ◽  
A. Zdragas ◽  
M. Yiangou
Keyword(s):  
Activated Carbon ◽  
Municipal Wastewater ◽  
Interleukin 1 ◽  
Granular Activated Carbon ◽  
Municipal Wastewater Treatment ◽  
Tertiary Treatment ◽  
Reclaimed Wastewater ◽  
Test Species ◽  
Mouse Splenocytes ◽  
Battery Of Bioassays

A battery of bioassays, including biological toxicity as well as in vitro mouse spleen lymphoproliferative responses and cytokine production, was conducted to compare the effectiveness of tertiary treatment methods such as coagulation (Coag) and absorption on granular activated carbon (GAC) and disinfection processes such as chlorination and ozonation in removing toxic or stress inducing agents from reclaimed wastewater. Whole effluent toxicity (WET) testing of secondary treated (ST) wastewater using as test species Vibrio fischeri, Daphnia magna and Tetrahymena thermophila as well as phytotoxicity revealed moderate toxicity effects that depend on the organism used. All bioassays exhibited decrease of the ecotoxicological responses after tertiary treatment. However, mitogenic responses were proved to be more sensitive. Endotoxin present in ST samples may be responsible for the increased strong lymphoproliferative activity as well as interleukin-1 (IL-1) production by mouse splenocytes. Tertiary treatment of ST with coagulation and/or adsorption on granular activated carbon (GAC) in combination with ozonation reduced WET to control levels. Ozonation alone or in combination with any other treatment removed endotoxin more efficiently than chlorination and thus reduced spleen lymphoproliferative responses and IL-1 production.

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