Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score–matched cohort study

Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality in patients with cancer, especially breast cancer, but their influence on second cancer risk is uncertain. This study aimed to examine whether NSAID use is associated with second cancer risk in patients with breast cancer. This population-based propensity score-matched cohort study using Taiwan’s National Health Insurance Research Database enrolled patients with newly diagnosed breast cancer (n = 7356) with and without (n = 1839) NSAID therapy from 2000 to 2009. They were followed up until the diagnosis of second cancer, death, or end of 2011. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR). The NSAID cohort had a lower incidence rate of second cancer than the non-NSAID cohort (5.57 vs. 9.19 per 1,000 person-years), with an aHR of 0.63 (95% confidence interval (CI) 0.46–0.87). When compared with the non-NSAID cohort, the second cancer incidence was lower in patients taking non-cyclooxygenase 2 inhibitors (aHR 0.67, 95% CI 0.47–0.94) and in those receiving multiple NSAIDs during follow-up (aHR 0.55, 95% CI 0.37–0.84). A dose–response relationship existed in NSAID cumulative days. The findings demonstrate that NSAID use reduces second cancer risk in a dose-dependent manner in patients with primary breast cancer.

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THE CHARACTERISTICS AND PROGNOSIS OF HEART FAILURE ASSOCIATED WITH CHEMOTHERAPY FOR EARLY BREAST CANCER: A POPULATION-BASED MATCHED COHORT STUDY

Canadian Journal of Cardiology ◽

10.1016/j.cjca.2021.07.123 ◽

2021 ◽

Vol 37 (10) ◽

pp. S59-S60

Author(s):

H Abdel-qadir ◽

F Tai ◽

R Croxford ◽

P Austin ◽

E Amir ◽

...

Keyword(s):

Breast Cancer ◽

Heart Failure ◽

Cohort Study ◽

Early Breast Cancer ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study

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Steroidal aromatase inhibitors have a more favorable effect on lipid profiles than nonsteroidal aromatase inhibitors in postmenopausal women with early breast cancer: a prospective cohort study

Therapeutic Advances in Medical Oncology ◽

10.1177/1758835920925991 ◽

2020 ◽

Vol 12 ◽

pp. 175883592092599

Author(s):

Xue Wang ◽

Anjie Zhu ◽

Jiayu Wang ◽

Fei Ma ◽

Jing Liu ◽

...

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Postmenopausal Women ◽

Early Breast Cancer ◽

Aromatase Inhibitors ◽

Cumulative Incidence ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipid Profiles ◽

Lipoprotein Cholesterol

Background: Aromatase inhibitors (AIs) influence blood lipid profiles. However, relatively few studies have directly compared the treatment effects of steroidal and nonsteroidal AIs. Methods: A prospective single-center cohort study was conducted to investigate the effects of steroidal and nonsteroidal AIs on lipid profiles during the first 24 months of endocrine therapy in hormone receptor-positive postmenopausal patients with early breast cancer. The primary endpoint was the cumulative incidence of lipid events, while the secondary endpoints were changes in lipid profiles and lipid event-free survival. Results: Comparison of the lipid profiles of the two groups showed that triglycerides (TGs) and total cholesterol (TC) levels were significantly higher in the nonsteroidal AI group over 24 months ( p < 0.05), whereas low-density lipoprotein cholesterol (LDL-C) was significantly higher only at 3 months ( p = 0.017) and 6 months ( p = 0.026). High-density lipoprotein cholesterol (HDL-C) was significantly lower in the steroidal group at all time points ( p < 0.05), except at 18 months ( p = 0.085). The cumulative incidence of lipid events in the steroidal and nonsteroidal groups at 24 months was 25.3% and 37.0%, respectively. Multivariate analysis results indicated that TG, LDL-C, and steroidal AIs were independently associated with blood lipid events. Conclusion: This trial showed that a significantly higher cumulative incidence of lipid events occurred in the nonsteroidal AI group than in the steroidal AI group, which indicated that steroidal AIs exerted a protective effect against blood lipid events in postmenopausal women receiving an AI as adjuvant therapy for breast cancer. ClinicalTrials.gov identifier: NCT02765373

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