Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: II. High-dose cisplatin is well tolerated by the native lung tissue*1

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.

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Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases☆☆☆

European Journal of Cardio-Thoracic Surgery ◽

10.1016/j.ejcts.2010.03.048 ◽

2010 ◽

Vol 38 (5) ◽

pp. 621-627 ◽

Cited By ~ 22

Author(s):

Willem A. Den Hengst ◽

Bart P. Van Putte ◽

Jeroen M.H. Hendriks ◽

Bernard Stockman ◽

Wim-Jan P. van Boven ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Lung Metastases ◽

Lung Perfusion ◽

Phase I Clinical Trial ◽

Term Survival ◽

Long Term Survival ◽

Isolated Lung Perfusion ◽

Isolated Lung

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Osteosarcoma with lung metastases

Pediatric Hematology/Oncology and Immunopathology ◽

10.24287/1726-1708-2019-18-4-127-135 ◽

2019 ◽

Vol 18 (4) ◽

pp. 127-135 ◽

Cited By ~ 1

Author(s):

I. V. Zhilkin ◽

D. G. Akhaladze ◽

D. V. Litvinov ◽

N. G. Uskova ◽

M. V. Tihonova ◽

...

Keyword(s):

Bone Tumor ◽

Pulmonary Metastases ◽

Lung Metastases ◽

Lung Perfusion ◽

Surgical Approaches ◽

Lung Lesions ◽

Isolated Lung Perfusion ◽

Isolated Lung ◽

Metastatic Lung ◽

Additional Option

Osteosarcoma is the bone tumor that most commonly affects children and adolescents. Before the introduction of polychemotherapy > 90% of patients with osteosarcoma died from pulmonary metastases. Despite development of new protocols of therapy in 30–40% of patients the disease is recurrent, more than 80% of them detected pulmonary metastasis. In this review we discussed the problems of detection of metastatic lung lesions and current approaches of methods of detection and marking of small sized metastatic lung lesions. An additional option in the treatment of lung metastases is intraoperative isolated lung perfusion, surgical approaches of which were also discussed.

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