Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives

2004 ◽  
Vol 39 (6) ◽  
pp. 535-545 ◽  
Author(s):  
Mohd Amir ◽  
Kumar Shikha
Keyword(s):  
Lipid Peroxidation ◽  
Acetic Acid ◽  
Phenyl Acetic Acid ◽  
Anti Inflammatory

scholarly journals Protective Effect ofFlos Loniceraeagainst Experimental Gastric Ulcers in Rats: Mechanisms of Antioxidant and Anti-Inflammatory Action

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jung-Woo Kang ◽  
Nari Yun ◽  
Hae-Jung Han ◽  
Jeom-Yong Kim ◽  
Joo-Young Kim ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Mrna Expression ◽  
Inflammatory Cytokines ◽  
Gastric Wall ◽  
Myeloperoxidase Activity ◽  
Flos Lonicerae ◽  
Anti Inflammatory

Flos Loniceraeis one of the oldest and most commonly prescribed herbs in Eastern traditional medicine to treat various inflammatory diseases. In the present study, we investigated the effects of ethyl acetate fraction ofFlos Lonicerae(GC-7101) on experimental gastric ulcer models and its mechanisms of action in gastric ulcer healing. The pharmacological activity of GC-7101 was investigated in rats on HCl/EtOH, indomethacin, water immersion restraint stress induced acute gastric ulcer, and acetic-acid-induced subchronic gastric ulcer. To determine its gastroprotective mechanisms, gastric wall mucus secretion, mucosal PGE2, mucosal NO content, nuclear translocation of NF-κB, mRNA expression of inflammatory cytokines, lipid peroxidation and glutathione content, and superoxide dismutase and catalase activities were measured. GC-7101 significantly attenuated development of acute gastric ulcer and accelerated the healing of acetic-acid-induced subchronic gastric ulcer. In HCl/EtOH-induced gastric ulcer, GC-7101 markedly enhanced gastric wall mucus content which was accompanied by increased mucosal PGE2and NO production. Furthermore, treatment of GC-7101 exhibited anti-inflammatory and antioxidant activities as evidenced by decreased myeloperoxidase activity, NF-κB translocation, inflammatory cytokines mRNA expression, and lipid peroxidation and increased glutathione content and superoxide dismutase and catalase activities. These results demonstrated that GC-7101 possesses strong antiulcerogenic effect by modulating oxidative stress and proinflammatory mediators.

scholarly journals SYNTHESIS, CHARACTERIZATION AND COMPARATIVE SCREENING OF SOME NEWER 2-PHENYL INDOLE AND 5-CHLORO-2-PHENYL INDOLE DERIVATIVES

2012 ◽  
Vol 20 (20) ◽  
pp. 69-76
Author(s):  
Vishal CHAUBAN ◽  
Sbivkanya FULORIA ◽  
Neeraj K. FULORIA ◽  
Syed R. HASHIM ◽  
Sokindra KUMAR
Keyword(s):  
Acetic Acid ◽  
Biologically Active ◽  
Aluminium Chloride ◽  
Spectral Studies ◽  
Indole Derivatives ◽  
Phenyl Acetic Acid ◽  
Microbial Activities ◽  
Anti Inflammatory

Biologically active phenyl indole and chloro phenyl indole derivatives were efficiently synthesized. The reaction of 2-phenyl-1H-indole A and 5-chloro-2-phenyl-1H-indole B, with chloroacetylchloride yielded 2-chloro-1-(2-phenyl-1H-indol-1-yl)ethanone 1 and 2-chloro-1-(5-chloro-2-phenyl-1H-indol-1-yl)ethanone 4 respectively. Compound 1 and 4 on Friedal Crafts cyclization in presence of aluminium chloride and nitrobenzene yielded indolo[2,1 -alfa]isoquinolin-6(5H)-one 2 and 10-chloroindolo [2,1-alfa]isoquinolin-6(5H)-one 5 respectively, which upon hydrolysis afforded 2-(2-(1H-indol-2-yl)phenyl)acetic acid 3 and 2-(2-(5-chloro-1H-indol-2-yl) phenyl) acetic acid 6 respectively. The newly designed compounds were characterized on the basis of spectral studies and screened for anti-inflammatory andanti-microbial activities.

Synthesis, conformational assignment, and anti-inflammatory activities of N-arylidene-2-(4-chloro-2-(2-substituted phenoxy)phenyl)acetic acid hydrazides

2016 ◽  
Vol 25 (10) ◽  
pp. 2220-2236 ◽  
Author(s):  
Afraz Nakhostin ◽  
Samaneh Mirseyyedhosein ◽  
Mahsa Toolabi ◽  
Pariya Khodabakhsh ◽  
Helia Aghamiri ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenyl Acetic Acid ◽  
Anti Inflammatory

On-Demand Guest Release from MOF-5 Sealed with Nitrophenylacetic Acid Photocapping Groups

2019 ◽  
Author(s):  
Jingjing Yan ◽  
Rick Homan ◽  
Corrianna Boucher ◽  
Prem N. Basa ◽  
Katherine Fossum ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Crystal Violet ◽  
Dye Molecules ◽  
Phenyl Acetic Acid ◽  
On Demand ◽  
Crystal Violet Dye ◽  
Dye Diffusion ◽  
Triphenylacetic Acid

Recently, we demonstrated that triphenylacetic acid could be used to seal dye molecules within MOF-5, but guest release required digestion of the framework by treatment with acid. We prepared the sterically bulky photocapping group [bis-(3-nitro-benzyl)-amino]-(3-nitro-phenyl)-acetic acid (PC1) can prevent Crystal violet dye diffusion from inside MOF-5 until removed by photolysis.

On-Demand Guest Release from MOF-5 Sealed with Nitrophenylacetic Acid Photocapping Groups

2019 ◽  
Author(s):  
Jingjing Yan ◽  
Rick Homan ◽  
Corrianna Boucher ◽  
Prem N. Basa ◽  
Katherine Fossum ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Crystal Violet ◽  
Dye Molecules ◽  
Phenyl Acetic Acid ◽  
On Demand ◽  
Crystal Violet Dye ◽  
Dye Diffusion ◽  
Triphenylacetic Acid

Recently, we demonstrated that triphenylacetic acid could be used to seal dye molecules within MOF-5, but guest release required digestion of the framework by treatment with acid. We prepared the sterically bulky photocapping group [bis-(3-nitro-benzyl)-amino]-(3-nitro-phenyl)-acetic acid (PC1) can prevent Crystal violet dye diffusion from inside MOF-5 until removed by photolysis.

scholarly journals Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Hee-Geun Jo ◽  
Geon-Yeong Lee ◽  
Chae Yun Baek ◽  
Ho Sueb Song ◽  
Donghun Lee
Keyword(s):  
Acetic Acid ◽  
Weight Bearing ◽  
Bone Diseases ◽  
Joint Disease ◽  
Root Extracts ◽  
Raw264.7 Macrophages ◽  
Age Related ◽  
Monosodium Iodoacetate ◽  
Anti Inflammatory

Osteoarthritis (OA) is an age-related joint disease and one of the most common degenerative bone diseases among elderly people. The currently used therapeutic strategies relying on nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids for OA are often associated with gastrointestinal, cardiovascular, and kidney disorders, despite being proven effective. Aucklandia lappa is a well-known traditional medicine. The root of A. lappa root has several bioactive compounds and has been in use as a natural remedy for bone diseases and other health conditions. We evaluated the A. lappa root extracts on OA progression as a natural therapeutic agent. A. lappa substantially reduced writhing numbers in mice induced with acetic acid. Monosodium iodoacetate (MIA) was injected into the rats through their knee joints of rats to induce experimental OA, which shows similar pathological characteristics to OA in human. A. lappa substantially reduced the MIA-induced weight-bearing of hind limb and reversed the cartilage erosion in MIA rats. IL-1β, a representative inflammatory mediator in OA, was also markedly decreased by A. lappa in the serum of MIA rats. In vitro, A. lappa lowered the secretion of NO and suppressed the IL-1β, COX-2, IL-6, and iNOS production in RAW264.7 macrophages activated with LPS. Based on its analgesic and anti-inflammatory effects, A. lappa could be a potential remedial agent against OA.

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