Ligand binding studies, preliminary structure–activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2015.08.021 ◽

2015 ◽

Vol 103 ◽

pp. 600-614 ◽

Cited By ~ 19

Author(s):

Bharath Srinivasan ◽

Sam Tonddast-Navaei ◽

Jeffrey Skolnick

Keyword(s):

Escherichia Coli ◽

Ligand Binding ◽

Dihydrofolate Reductase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Binding Studies ◽

Structure Activity

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Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth

Journal of Medicinal Chemistry ◽

10.1021/jm00390a017 ◽

1987 ◽

Vol 30 (7) ◽

pp. 1218-1224 ◽

Cited By ~ 24

Author(s):

Raymond G. Booth ◽

Cynthia Dias Selassie ◽

Corwin Hansch ◽

Daniel V. Santi

Keyword(s):

Cell Growth ◽

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Of

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Microscale characterization of the structure–activity relationship of a heparin-binding glycopeptide using affinity capillary electrophoresis and immobilized enzymes

Journal of Chromatography A ◽

10.1016/s0021-9673(99)00452-5 ◽

1999 ◽

Vol 853 (1-2) ◽

pp. 189-195 ◽

Cited By ~ 11

Author(s):

Niels H.H Heegaard

Keyword(s):

Capillary Electrophoresis ◽

Immobilized Enzymes ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Heparin Binding ◽

Affinity Capillary Electrophoresis ◽

Structure Activity ◽

Relationship Of

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nSynthesis and characterization of 1-amidino-O-alkylureas metal complexes as α- glucosidase Inhibitors: Structure-activity relationship, molecular docking, and kinetic studies

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131726 ◽

2021 ◽

pp. 131726

Author(s):

Firouz Matloubi Moghaddam ◽

Maryam Daneshfar ◽

Zahra Daneshfar ◽

Aida Iraji ◽

Atefe Samandari-Najafabad ◽

...

Keyword(s):

Molecular Docking ◽

Metal Complexes ◽

Kinetic Studies ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Glucosidase Inhibitors

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ChemInform Abstract: INHIBITION OF HUMAN DIHYDROFOLATE REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINES. A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS

Chemischer Informationsdienst ◽

10.1002/chin.198429225 ◽

1984 ◽

Vol 15 (29) ◽

Author(s):

B. A. HATHAWAY ◽

Z. GUO ◽

C. HANSCH ◽

T. J. DELCAMP ◽

S. S. SUSTEN ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Human Dihydrofolate Reductase

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Quantitative Structure Activity Relationship Study of 2,4,6-Trisubstituted-s-triazine Derivatives as Antimalarial Inhibitors of Plasmodium Falciparum Dihydrofolate Reductase

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2010.01045.x ◽

2010 ◽

Vol 77 (1) ◽

pp. 57-62 ◽

Cited By ~ 16

Author(s):

Himanshu Ojha ◽

Pragya Gahlot ◽

Anjani K. Tiwari ◽

Mallika Pathak ◽

Rita Kakkar

Keyword(s):

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Triazine Derivatives ◽

Relationship Study

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Structure-activity relationship and design of an antimutagen against the UV-induced mutation of Escherichia coli.

Agricultural and Biological Chemistry ◽

10.1271/bbb1961.50.625 ◽

1986 ◽

Vol 50 (3) ◽

pp. 625-631 ◽

Cited By ~ 9

Author(s):

Katsumi KAKINUMA ◽

Junpei KOIKE ◽

Keiji ISHIBASHI ◽

Wataru TAKAHASHI ◽

Hisashi TAKEI

Keyword(s):

Escherichia Coli ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Induced Mutation ◽

Structure Activity

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Structure–activity relationship of a series of 1,2-dihydroquinoline analogues and binding mode with Vibrio cholerae dihydrofolate reductase

Medicinal Chemistry Research ◽

10.1007/s00044-016-1583-1 ◽

2016 ◽

Vol 25 (8) ◽

pp. 1524-1537 ◽

Cited By ~ 2

Author(s):

Vítor W. Rabelo ◽

Thienne F. Sampaio ◽

Lívia D. Duarte ◽

Desirée H. B. Lopes ◽

Paula A. Abreu

Keyword(s):

Vibrio Cholerae ◽

Dihydrofolate Reductase ◽

Binding Mode ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Compound toxicity screening and structure-activity relationship modeling in Escherichia coli

Biotechnology and Bioengineering ◽

10.1002/bit.24356 ◽

2011 ◽

Vol 109 (3) ◽

pp. 846-850 ◽

Cited By ~ 36

Author(s):

Anne-Gaëlle Planson ◽

Pablo Carbonell ◽

Elodie Paillard ◽

Nicolas Pollet ◽

Jean-Loup Faulon

Keyword(s):

Escherichia Coli ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Toxicity Screening ◽

Structure Activity

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Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P5(Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors†

Biochemistry ◽

10.1021/bi011606i ◽

2001 ◽

Vol 40 (46) ◽

pp. 14053-14060 ◽

Cited By ~ 58

Author(s):

Dong-Soon Im ◽

Jeremy Clemens ◽

Timothy L. Macdonald ◽

Kevin R. Lynch

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Sphingosine 1 Phosphate ◽

Relationship Of ◽

Human And Mouse

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Expression of an active alpha scorpion neurotoxin using Escherichia coli, insect cells and lepidopterous larvae: structure-activity relationship and future applications

Toxicon ◽

10.1016/0041-0101(95)99267-7 ◽

1995 ◽

Vol 33 (3) ◽

pp. 269 ◽

Cited By ~ 2

Author(s):

N. Zilberberg ◽

D. Gordon ◽

E. Zlotkin ◽

M. Pelhate ◽

N. Chejanovsky ◽

...

Keyword(s):

Escherichia Coli ◽

Insect Cells ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Scorpion Neurotoxin

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