Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer

2018 ◽  
Vol 143 ◽  
pp. 1616-1634 ◽  
Author(s):  
Andrea Bistrović ◽  
Luka Krstulović ◽  
Anja Harej ◽  
Petra Grbčić ◽  
Mirela Sedić ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Biological Evaluation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents

2020 ◽  
Vol 11 (2) ◽  
pp. 293-296
Author(s):  
Liang Jiang ◽  
Xiaolu Wang ◽  
Yuting Wang ◽  
Fang Xu ◽  
Zhang Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Biological Evaluation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation ◽  
Cancer Activity

A novel series of sanguinarine (SA) derivatives were synthesized and firstly evaluated as anti-NSCLC agents. The SARs studies suggested that the CN+ bond was critical for anti-cancer activity and the C6-position was tolerated to be substituted by hydrophilic groups and CN.

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