scholarly journals Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis

2020 ◽  
Vol 201 ◽  
pp. 112408 ◽  
Author(s):  
Marzena Baran ◽  
Kimberly D. Grimes ◽  
Paul A. Sibbald ◽  
Peng Fu ◽  
Helena I.M. Boshoff ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Fatty Acyl

High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU

Tuberculosis ◽  
2015 ◽  
Vol 95 (6) ◽  
pp. 664-677 ◽  
Author(s):  
Chitra Rani ◽  
Rukmankesh Mehra ◽  
Rashmi Sharma ◽  
Reena Chib ◽  
Priya Wazir ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Small Molecule ◽  
High Throughput ◽  
Small Molecule Inhibitors ◽  
High Throughput Screen ◽  
Acetyltransferase Activity

Biochemical characterization of ClpB protein from Mycobacterium tuberculosis and identification of its small-molecule inhibitors

2020 ◽  
Vol 165 ◽  
pp. 375-387
Author(s):  
Prashant Singh ◽  
Harleen Khurana ◽  
Shiv Pratap Yadav ◽  
Kanika Dhiman ◽  
Padam Singh ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biochemical Characterization

scholarly journals A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

2016 ◽  
Vol 14 (7) ◽  
pp. 2318-2326 ◽  
Author(s):  
Petar O. Nikiforov ◽  
Sachin Surade ◽  
Michal Blaszczyk ◽  
Vincent Delorme ◽  
Priscille Brodin ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Small Molecule ◽  
Small Molecule Inhibitors

With the ever-increasing instances of resistance to frontline TB drugs there is the need to develop novel strategies to fight the worldwide TB epidemic.

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