Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities

2021 ◽  
Vol 210 ◽  
pp. 112984
Author(s):  
Lin An ◽  
Chan Wang ◽  
You-Guang Zheng ◽  
Jia-dong Liu ◽  
Tong-hui Huang
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis ◽  
Amide Derivatives

scholarly journals Design, Synthesis of Amide Derivatives of Scutellarin And Their Anti-Leukemia And Neuroprotective Activities

2022 ◽  
Author(s):  
Tong Han ◽  
Chunyu Jiang ◽  
Xing Wei ◽  
Meilin Sheng ◽  
Qin Xie ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Injury ◽  
Neuroprotective Activity ◽  
Antitumor Activities ◽  
Leukaemia Cell ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Human Leukaemia Cell ◽  
Human Leukaemia

Abstract A unique series of amide-scutellarin derivatives were designed and synthesized in order to develop the function of scutellarin further. The antiproliferative activity of all target compounds against two human leukaemia cell lines were evaluated. Among them, compounds 6g and 7c displayed the most antitumor activities against HL-60 and THP-1. Moreover, all compounds were also assayed for their neuroprotective activity against hydrogen peroxide (H2O2)-induced PC-12 cell injury, and the majority of the compounds had moderate to good neuroprotective properties. These findings confirmed that these target compounds could be used as anti-leukaemia and neuroprotective candicates in the future.

Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita

2021 ◽  
Vol 40 ◽  
pp. 127917
Author(s):  
Haiping Yang ◽  
Ruifeng Zhang ◽  
Zhong Li ◽  
Peter Maienfisch ◽  
Xiaoyong Xu
Keyword(s):  
Meloidogyne Incognita ◽  
Design Synthesis ◽  
Amide Derivatives

Amide derivatives of 4-azaindole: Design, synthesis, and EGFR targeting anticancer agents

2019 ◽  
Vol 50 (1) ◽  
pp. 71-84 ◽  
Author(s):  
Puli Venkat Swamy ◽  
Vukoti Kiran Kumar ◽  
Ruddarraju Radhakrishnam Raju ◽  
Regalla Venkata Reddy ◽  
Anindita Chatterjee ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Derivatives Of

Design, synthesis and biological activity of novel substituted pyrazole amide derivatives targeting EcR/USP receptor

2016 ◽  
Vol 27 (4) ◽  
pp. 566-570 ◽  
Author(s):  
Xi-Le Deng ◽  
Jin Xie ◽  
Yong-Qiang Li ◽  
De-Kai Yuan ◽  
Xue-Ping Hu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Design Synthesis ◽  
Amide Derivatives

scholarly journals Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists

Molecules ◽  
2014 ◽  
Vol 19 (3) ◽  
pp. 3539-3551 ◽  
Author(s):  
Libao Xu ◽  
Yang Zhang ◽  
Wenjie Dai ◽  
Ying Wang ◽  
Dan Jiang ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Amide Derivatives ◽  
Sar Study

scholarly journals Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3766
Author(s):  
Zai-Bo Yang ◽  
Pei Li ◽  
Yin-Ju He
Keyword(s):  
Enzyme Activity ◽  
Mosaic Virus ◽  
Antiviral Agents ◽  
Plant Tolerance ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Induce Resistance ◽  
Antiviral Activities ◽  
Related Enzyme

As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Antiviral bioassays indicated that some of the target compounds exhibited better in vivo antiviral activities against TMV and CMV than those of Ningnanmycin (NNM). Especially, the compound 7t exhibited the best curative, protection, and inactivation activities against TMV and CMV which were superior to those of NNM. Meanwhile, our present work also revealed that compound 7t could enhance the defense-related enzyme activity and increase the chlorophyll content in tobacco leaves to induce resistance and enhance plant tolerance to TMV infection.

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