Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile

2021 ◽  
pp. 113895
Author(s):  
Simona Sestito ◽  
Andrea Bacci ◽  
Sara Chiarugi ◽  
Massimiliano Runfola ◽  
Francesca Gado ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Lead Optimization ◽  
Structural Insights

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Mini-Review: Bmx Kinase Inhibitors for Cancer Therapy

2013 ◽  
Vol 8 (3) ◽  
pp. 228-238 ◽  
Author(s):  
John Jarboe ◽  
Shilpa Dutta ◽  
Sadanandan Velu ◽  
Christopher Willey
Keyword(s):  
Cancer Therapy ◽  
Kinase Inhibitors

Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy

2019 ◽  
Vol 63 (1) ◽  
pp. 122-139 ◽  
Author(s):  
Junwei Wang ◽  
Hui Li ◽  
Guangchao He ◽  
Zhaoxing Chu ◽  
Kewen Peng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Promising Strategy ◽  
Phosphoinositide 3 Kinase

Kinase Inhibitors in Multitargeted Cancer Therapy

2017 ◽  
Vol 24 (16) ◽  
Author(s):  
Carla Gentile ◽  
Annamaria Martorana ◽  
Antonino Lauria ◽  
Riccardo Bonsignore
Keyword(s):  
Cancer Therapy ◽  
Kinase Inhibitors

Evolution strategy of ROS1 kinase inhibitors for use in cancer therapy

2018 ◽  
Vol 10 (14) ◽  
pp. 1705-1720 ◽  
Author(s):  
Siming Liu ◽  
Haikui Yang ◽  
Ying Jiang ◽  
Tingting Zhang ◽  
Ruohong Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Evolution Strategy
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