Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy

Design Synthesis ◽

High Affinity ◽

Deacetylase Inhibitor ◽

Biochemical Evaluation

P21-Driven Multifusion Gene System for Evaluating the Efficacy of Histone Deacetylase Inhibitors by In Vivo Molecular Imaging and for Transcription Targeting Therapy of Cancer Mediated by Histone Deacetylase Inhibitor

Journal of Nuclear Medicine ◽

10.2967/jnumed.113.126573 ◽

2014 ◽

Vol 55 (4) ◽

pp. 678-685 ◽

Cited By ~ 4

Author(s):

Y.-J. Hsieh ◽

L. Hwu ◽

Y.-C. Chen ◽

C.-C. Ke ◽

F.-D. Chen ◽

...

Keyword(s):

Molecular Imaging ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Targeting Therapy ◽

Gene System ◽

CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-06-0042 ◽

2006 ◽

Vol 5 (7) ◽

pp. 1693-1701 ◽

Cited By ~ 19

Author(s):

Z. Alexander Cao ◽

Kathryn E. Bass ◽

Sriram Balasubramanian ◽

Liang Liu ◽

Brian Schultz ◽

...

Keyword(s):

Histone Deacetylase ◽

Broad Spectrum ◽

Antiangiogenic Activity ◽

Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer Cells

Journal of Cancer ◽

10.7150/jca.16655 ◽

2017 ◽

Vol 8 (1) ◽

pp. 19-28 ◽

Cited By ~ 16

Author(s):

Aneta Grabarska ◽

Jarogniew J. Łuszczki ◽

Ewa Nowosadzka ◽

Ewelina Gumbarewicz ◽

Witold Jeleniewicz ◽

...

Keyword(s):

Targeted Therapy ◽

Cancer Cells ◽

Histone Deacetylase ◽

Larynx Cancer ◽

Tissue-Targeted In Vivo Gene Transfer Coupled with Histone Deacetylase Inhibitor Depsipeptide (FK228) Enhances Adenoviral Infection in Rat Renal Cancer Allograft Model Systems

Urology ◽

10.1016/j.urology.2007.09.022 ◽

2007 ◽

Vol 70 (6) ◽

pp. 1230-1236 ◽

Cited By ~ 5

Author(s):

Minoru Kobayashi ◽

Takashi Okada ◽

Takashi Murakami ◽

Keiya Ozawa ◽

Eiji Kobayashi ◽

...

Keyword(s):

Gene Transfer ◽

Histone Deacetylase ◽

Renal Cancer ◽

Model Systems ◽

Adenoviral Infection ◽

Deacetylase Inhibitor ◽

In Vivo Gene Transfer

Synergistic In vivo Antitumor Effect of the Histone Deacetylase Inhibitor MS-275 in Combination with Interleukin 2 in a Murine Model of Renal Cell Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-0014 ◽

2007 ◽

Vol 13 (15) ◽

pp. 4538-4546 ◽

Cited By ~ 59

Author(s):

Yukihiko Kato ◽

Kiyoshi Yoshimura ◽

Tahiro Shin ◽

Henk Verheul ◽

Hans Hammers ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Histone Deacetylase ◽

Murine Model ◽

Renal Cell ◽

Antitumor Effect ◽

Interleukin 2 ◽

Evaluation of the Antitumor Efficacy, Pharmacokinetics, and Pharmacodynamics of the Histone Deacetylase Inhibitor Depsipeptide in Childhood Cancer Models In vivo

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-05-1225 ◽

2006 ◽

Vol 12 (1) ◽

pp. 223-234 ◽

Cited By ~ 67

Author(s):

Claire Graham ◽

Chandra Tucker ◽

Jeremy Creech ◽

Edward Favours ◽

Catherine A. Billups ◽

...

Keyword(s):

Childhood Cancer ◽

Histone Deacetylase ◽

Antitumor Efficacy ◽

Pharmacokinetics And Pharmacodynamics ◽

Cancer Models ◽

Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

Journal of Hepatology ◽

10.1016/j.jhep.2011.07.013 ◽

2012 ◽

Vol 56 (1) ◽

pp. 176-183 ◽

Cited By ~ 32

Author(s):

Huanjie Shao ◽

Chun Gao ◽

Haikuo Tang ◽

Hao Zhang ◽

Lewis R. Roberts ◽

...

Keyword(s):

Histone Deacetylase ◽

Dual Targeting ◽

Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo

Biochemical Pharmacology ◽

10.1016/s0006-2952(02)01261-3 ◽

2002 ◽

Vol 64 (7) ◽

pp. 1079-1090 ◽

Cited By ~ 63

Author(s):

Yuka Sasakawa ◽

Yoshinori Naoe ◽

Takeshi Inoue ◽

Tatsuya Sasakawa ◽

Masahiko Matsuo ◽

...

Keyword(s):

Histone Deacetylase ◽

Deacetylase Inhibitor ◽

Human Lymphoma

Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.11.005 ◽

2015 ◽

Vol 23 (24) ◽

pp. 7597-7606 ◽

Cited By ~ 16

Author(s):

Rodrigo Mendoza-Sanchez ◽

David Cotnoir-White ◽

Justyna Kulpa ◽

Isabel Jutras ◽

Joshua Pottel ◽

...

Keyword(s):

Histone Deacetylase ◽

Design Synthesis ◽

Deacetylase Inhibitor ◽

Molecular Hybrids

Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53

International Journal of Biological Sciences ◽

10.7150/ijbs.45505 ◽

2020 ◽

Vol 16 (16) ◽

pp. 3184-3199

Author(s):

Batsaikhan Buyandelger ◽

Eli E Bar ◽

Kuo-Sheng Hung ◽

Ruei-Ming Chen ◽

Yung-Hsiao Chiang ◽

...

Keyword(s):

Histone Deacetylase ◽

Deacetylase Inhibitor ◽

Glioma Growth