2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and Antiglaucoma activity

2021 ◽  
pp. 114026
Author(s):  
Niccolò Chiaramonte ◽  
Andrea Angeli ◽  
Silvia Sgambellone ◽  
Alessandro Bonardi ◽  
Alessio Nocentini ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Enzyme Inhibition ◽  
Computational Studies ◽  
Carbonic Anhydrase Inhibitors ◽  
Piperazine Derivatives ◽  
Human Carbonic Anhydrase ◽  
Hydroxyethyl Piperazine

In-Silico Analysis of Chromone Containing Sulfonamide Derivatives as Human Carbonic Anhydrase Inhibitors

2013 ◽  
Vol 9 (4) ◽  
pp. 608-616 ◽  
Author(s):  
Zaheer Ul-Haq ◽  
Saman Usmani ◽  
Uzma Mahmood ◽  
Mariya al-Rashida ◽  
Ghulam Abbas
Keyword(s):  
Carbonic Anhydrase ◽  
In Silico ◽  
In Silico Analysis ◽  
Carbonic Anhydrase Inhibitors ◽  
Human Carbonic Anhydrase ◽  
Silico Analysis

Out of the active site binding pocket for carbonic anhydrase inhibitors

2015 ◽  
Vol 51 (2) ◽  
pp. 302-305 ◽  
Author(s):  
Katia D'Ambrosio ◽  
Simone Carradori ◽  
Simona M. Monti ◽  
Martina Buonanno ◽  
Daniela Secci ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Active Site ◽  
Binding Pocket ◽  
Carbonic Anhydrase Ii ◽  
Carbonic Anhydrase Inhibitors ◽  
Human Carbonic Anhydrase ◽  
Site Binding

2-Benzylsulfinylbenzoic acid binds to human carbonic anhydrase II in a mode completely different from any other class of carbonic anhydrase inhibitors investigated so far.

Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors

2020 ◽  
Vol 97 ◽  
pp. 103658 ◽  
Author(s):  
Benas Balandis ◽  
Guostė Ivanauskaitė ◽  
Joana Smirnovienė ◽  
Kristina Kantminienė ◽  
Daumantas Matulis ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
Human Carbonic Anhydrase ◽  
Relationship Of
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