Normal tissue sparing potential of scanned proton beams with and without respiratory gating for the treatment of internal mammary nodes in breast cancer radiotherapy

2018 ◽  
Vol 52 ◽  
pp. 81-85 ◽  
Author(s):  
Alexandru Dasu ◽  
Anna M. Flejmer ◽  
Anneli Edvardsson ◽  
Petra Witt Nyström
2013 ◽  
Vol 99 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Ferrat Dincoglan ◽  
Murat Beyzadeoglu ◽  
Omer Sager ◽  
Kaan Oysul ◽  
Yelda Elcim Kahya ◽  
...  

Aims and background The aim of the study was to evaluate the dosimetric impact of the active breathing control-moderate deep inspiration breath-hold (ABC-mDIBH) technique on normal tissue sparing in locally advanced left-sided breast cancer radiotherapy. Methods and study design Twenty-seven consecutive patients with left-sided locally advanced breast cancer referred to our department for adjuvant radiotherapy were enrolled in the study. Each patient was scanned at free breathing and ABC-mDIBH for radiation treatment planning. Two separate radiotherapy treatment plans were generated with and without ABC-mDIBH to investigate the dosimetric impact of ABC-mDIBH in breast cancer radiotherapy. Results Between June 2011 and February 2012, 27 consecutive patients with left-sided locally advanced breast cancer referred to our department for adjuvant radiotherapy were enrolled in the study. Dose-volume parameters of left anterior descending coronary artery, lungs, heart, contralateral breast, esophagus and spinal cord were significantly reduced with the use of ABC-mDIBH ( P <0.001). Conclusions Our study revealed that the use of ABC-mDIBH in the practice of locally advanced mastectomized left-sided breast cancer radiotherapy improves normal tissue sparing with the expected potential of decreasing treatment-related morbidity and mortality. Moreover, the resultant reduction achieved with ABC in doses to the left anterior descending coronary artery, which plays a central role in cardiac perfusion, may have implications for decreasing the potential of radiation-induced cardiac morbidity and mortality.


2005 ◽  
Vol 63 (5) ◽  
pp. 1522-1530 ◽  
Author(s):  
Hans P. van der Laan ◽  
Wil V. Dolsma ◽  
Aart A. van ’t Veld ◽  
Hendrik P. Bijl ◽  
Johannes A. Langendijk

2016 ◽  
Vol 55 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Anna M. Flejmer ◽  
Anneli Edvardsson ◽  
Frida Dohlmar ◽  
Dan Josefsson ◽  
Mats Nilsson ◽  
...  

2012 ◽  
Vol 30 (4) ◽  
pp. 323-330 ◽  
Author(s):  
Philippe Giraud ◽  
Juliette Djadi-Prat ◽  
Magalie Morelle ◽  
Nicolas Pourel ◽  
Catherine Durdux ◽  
...  

2012 ◽  
Vol 82 (2) ◽  
pp. 724-731 ◽  
Author(s):  
Emi J. Yoshida ◽  
Hao Chen ◽  
Mylin Torres ◽  
Fundagul Andic ◽  
Hao-Yang Liu ◽  
...  

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