Ultrasonic assessment of the distribution of tricalcium phosphate filler over the volume of swollen porous matrices based on chitosan for biomedical applications

Regenerative medicine is a rapidly developing interdisciplinary field of science. Of primary interest are new materials and mechanisms of their interaction with living organisms. Investigation methods should provide 3D visualization and analysis of quantitative characteristics, while having no effect on the objects under study. For these purposes, methods based on ultrasound and those displaying variations in the elastic properties of samples are promising.

Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia

Objective. To evaluate monosodium urate (MSU) crystal deposition and related lesions in the joints of patients with gout and hyperuricemia (HUA) using ultrasound. To explore the association between ultrasound findings and clinical features in gout and HUA. Methods. A total of 202 patients with gout and 43 asymptomatic patients with HUA were included. The clinical data and ultrasonic assessment results were collected and statistically analyzed. Results. Deposition of MSU crystals was found in 25.58% (11/43) of patients with asymptomatic HUA and 76.24% (154/202) of patients with gout. Of the 1,082 joints from patients with gout examined, 33.09% (358/1082) displayed MSU crystal deposition. In the joints with MSU crystal deposition, 77.37% (277/358) had a history of attacks. Among the joints of gouty arthritis, double contour sign (DCS), hyperechoic aggregate (HAG), and tophi were found in 32.65% (159/487), 7.80% (38/487), and 24.64% (120/487) of the joints, respectively. DCS and tophi, but not HAG, increasingly appeared with the extension of gout duration. In patients with more than 15 years of gout history, DCS, Tophi, and HAG were found in 48.18%, 40.00%, and 6.36% of US assessed joints, respectively. In patients with gout, synovial lesion and bone erosion were found in 17.74% (192/1082) and 7.58% (82/1082) of joints, respectively. The synovial lesion was related to HAG, while bone erosion was related to tophi and DCS. Nephrolithiasis was detected in 20.30% (41/202) of patients with gout and 4.65% (2/43) of HUA patients, indicating that nephrolithiasis occurred in more patients with gout than in patients with HUA. Conclusion. HAG is an early performance of MSU crystal deposition in joints of gout and HUA. Both DCS and tophi are risk factors for bone erosion. Early urate-lowering therapy (ULT) should be considered in patients with gout, DCS, or tophi.

Ultrasonic Assessment of the Concrete Residual Strength after a Real Fire Exposure

After a fire, the assessment of concrete residual strength can be a challenge. Since the strength reduction depends on the distance from the heated surface examination based on destructive test, i.e., core samples, is not precise enough. Therefore, more detailed methods can establish the influence of the high temperature in the zone, which no longer has visible cracks. That method can be used to assess layer thickness to remove due to the fire damage. The Ultrasound Pulse Velocity (UPV) method with point heads was used in the paper to examine samples taken from a structure after the real fire. Moreover, to make the analysis more precise, an effect associated with the porosity in concrete was also considered to separate pure fire effect.