Clearance of high-risk human papillomavirus (HPV) DNA and PAP smear abnormalities in a cohort of women subjected to HPV screening in the New Independent States of the former Soviet Union (the NIS cohort study)

Author(s):  
S. Syrjänen ◽  
I.P. Shabalova ◽  
N. Petrovichev ◽  
V.P. Kozachenko ◽  
T. Zakharova ◽  
...  
2007 ◽  
Vol 16 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Satu-Maria A. Kulmala ◽  
Irena P. Shabalova ◽  
Nikolay Petrovitchev ◽  
Kari J. Syrjänen ◽  
Ulf B. Gyllensten ◽  
...  

2007 ◽  
Vol 79 (6) ◽  
pp. 771-781 ◽  
Author(s):  
Satu-Maria A. Kulmala ◽  
Irena P. Shabalova ◽  
Nikolay Petrovitchev ◽  
Kari J. Syrjänen ◽  
Ulf B. Gyllensten ◽  
...  

2003 ◽  
Vol 30 (9) ◽  
pp. 680-684 ◽  
Author(s):  
Stina Syrjänen ◽  
Irena Shabalova ◽  
Nicolaj Petrovichev ◽  
Vladimir Kozachenko ◽  
Tatjana Zakharova ◽  
...  

10.1068/b2658 ◽  
2000 ◽  
Vol 27 (3) ◽  
pp. 331-347 ◽  
Author(s):  
Tony Zamparutti ◽  
Brendan Gillespie

The 1993 Environmental Action Programme for Central and Eastern Europe presented a series of recommendations for integrating environmental objectives into the process of economic and democratic reform in Central and Eastern European countries (CEEC) and the New Independent States of the former Soviet Union (NIS). In this paper, on the basis of findings of a recent OECD study, we look at progress across the region in light of these recommendations. In several CEEC, there has been a synergy among economic reforms, democratic development, and environmental improvement. These countries have seen important improvements in environmental conditions but now face a variety of challenges, many tied to the process of accession to the EU and the need to deepen integration between environment and sectoral policies, such as those for agriculture and transport. In other countries, and in particular many NIS, pollution reductions have mainly resulted from declines in economic production. Many of these countries face ongoing crisis in terms of establishing economic reform, stable societies, and environmental protection. In several areas of the former Soviet Union, environmental problems—in particular poor access to safe drinking water—pose serious threats to human health. Addressing these problems presents a difficult challenge both for national governments and for international cooperation agencies.


2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Howard Minkoff ◽  
Ye Zhong ◽  
Howard D. Strickler ◽  
D. Heather Watts ◽  
Joel M. Palefsky ◽  
...  

Objective. Animal data suggest that cocaine has an immunosuppressive effect, but no human studies have been conducted to assess the relation of cocaine use with human papillomavirus (HPV) infection, the viral cause of cervical cancer. Since both cocaine use and HPV infection are common among HIV-positive women, we sought to determine whether use of cocaine and/or crack influences the natural history of HPV among women with or at high risk of HIV.Methods. Women enrolled in the Women's Interagency HIV Study (2278 HIV-seropositive and 826 high-risk seronegative women) were examined every six months for up to 9.5 years with Pap smear, collection of cervicovaginal lavage (CVL) samples, and detailed questionnaires regarding health and behavior, including use of crack and cocaine (crack/cocaine). CVLs were tested for HPV DNA by PCR, with genotyping for over forty HPV types.Results. In multivariate logistic regression models, censoring women treated for cervical neoplasia, crack/cocaine use within the last six months was associated with prevalent detection of oncogenic HPV DNA (odds ratio [OR] = 1.30 (1.09–1.55)), and with oncogenic HPV-positive squamous intraepithelial lesions (SIL) (OR = 1.70 (1.27–2.27)), following adjustment for age, race, HIV-serostatus, and CD4+ T-cell count, the number of sexual partners in the past six months, and smoking. In multivariate Cox models crack/cocaine use was also associated with a trend that approached significance in regard to incident detection of oncogenic HPV-positive SIL (HR = 1.51, 95% CI 0.99–2.30), and while the rate of oncogenic HPV clearance was not related to cocaine use, the clearance of any SIL was significantly lower in those with versus those without recent crack/cocaine use (HR = 0.57, 95% CI 0.34–0.97).Conclusions. Cocaine use is associated with an increased risk of detection of both prevalent and incident oncogenic HPV infection, as well as an increased risk of HPV-positive SIL over time.


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