Invasive cervical cancer following treatment of pre-invasive lesions: a potential theory based on a small case series

ObjectiveCervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy.MethodsIn our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines.ResultsAll the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months).ConclusionsEven if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.

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Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

BMC Cancer ◽

10.1186/s12885-021-07940-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Stanie Gaete ◽

Aviane Auguste ◽

Bernard Bhakkan ◽

Jessica Peruvien ◽

Cecile Herrmann-Storck ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

Population Based ◽

Multiple Infections ◽

French Caribbean ◽

Papilloma Virus ◽

Hpv Genotyping ◽

Hpv Status ◽

Hpv Genotypes ◽

High Risk Hpv

Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.

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Ketogenic Diet Therapy for Intractable Epilepsy in Infantile Alexander Disease: A Small Case Series and Analyses of Astroglial Chemokines and Proinflammatory Cytokines

Epilepsy Research ◽

10.1016/j.eplepsyres.2020.106519 ◽

2021 ◽

Vol 170 ◽

pp. 106519

Author(s):

Shu Hamada ◽

Takeo Kato ◽

Kengo Kora ◽

Tatsuya Kawaguchi ◽

Tenshin Okubo ◽

...

Keyword(s):

Ketogenic Diet ◽

Proinflammatory Cytokines ◽

Case Series ◽

Intractable Epilepsy ◽

Diet Therapy ◽

Alexander Disease ◽

Small Case Series

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Robotic versus open radical hysterectomy for invasive cervical cancer: A single institution review of the first 3years of practice

Gynecologic Oncology ◽

10.1016/j.ygyno.2011.07.041 ◽

2011 ◽

Vol 123 (2) ◽

pp. 430

Author(s):

M. Tenney ◽

E. Nugent ◽

J. Kimmer ◽

C. Mathews ◽

D.S. McMeekin ◽

...

Keyword(s):

Cervical Cancer ◽

Radical Hysterectomy ◽

Invasive Cervical Cancer ◽

Single Institution

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Challenges in Evaluation and Management of Children with Myocardial Bridging

Cardiology ◽

10.1159/000513900 ◽

2021 ◽

pp. 1-8

Author(s):

Nurdan Erol

Keyword(s):

Congenital Anomaly ◽

Coronary Artery ◽

Case Reports ◽

Case Series ◽

Diagnosis And Treatment ◽

Myocardial Bridging ◽

Small Case Series ◽

Adults And Children ◽

Artery Branch

Myocardial bridging (MB) is a congenital anomaly where a coronary artery branch or group of branches extends inside a tunnel consisting of myocardium. Although it is mostly considered “benign,” it is reported that MB may lead to significant cardiac problems and sudden cardiac deaths. While it is a congenital anomaly, its symptoms usually arise at further ages rather than childhood. The literature on MB in children is in the form of case reports or small case series. This is why pediatric cases are assessed in the light of information obtained from adults. This review compiled the literature on MB in adults and children and compared it, as well as discussing questions arising regarding the clinic, diagnosis, and treatment of MB.

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