Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a retrospective study in a single center

Abstract Purpose: Uterine smooth muscle tumors of uncertain malignant potential (STUMP) is a heterogeneous group of tumors with histological and biological diversity that cannot be defined as a benign leiomyoma or malignant leiomyosarcoma. The study aims to investigate the diagnostic methods, treatment management and prognosis of STUMP patients in a 13-year period. Methods: We retrospectively reviewed the clinicopathologic information of 31 STUMP patients in Peking University People’s Hospital. Statistical analyses were conducted to compare the difference of clinical characteristics between the women in myomectomy group and those in hysterectomy group. Results: The most common clinical presentation was menstrual disorder. The tumors were mainly manifested as hypoechoic, non-cystic nodules with low blood flow signal by pelvic doppler ultrasonography. Most tumors carried Ki-67 index ranging from 10% to 30%. Immunohistochemical markers such as ER, PR, p16 and Desmin was positively expressed in tumors. At the first operation, 21 cases underwent myomectomy and 10 cases underwent hysterectomy. The patients in myomectomy group were younger than those in hysterectomy group. In the follow-up period, two cases experienced a relapse in the form of STUMP within 36 months. One case died of cardiovascular accident while the other cases were alive. Six of 21 women in myomectomy group desired pregnancy and two healthy live births were recorded.Conclusion: The diagnosis of STUMP primarily depends on histopathologic features. Fertility-sparing surgery may be a treatment selection for patients with fertility desire. Patients with STUMP, especially in the case of myomectomy, should be informed of recurrence risk and monitored closely.

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A Case Report of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP) Mistaken with Ovarian Tumor in a Female with Polio

Journal of Obstetrics Gynecology and Cancer Research ◽

10.17795/ogcr-9425 ◽

2017 ◽

Vol In Press (In Press) ◽

Author(s):

Zahra Vahedpoor ◽

Tahereh Khamechian ◽

Nazila Zandi

Keyword(s):

Smooth Muscle ◽

Case Report ◽

Ovarian Tumor ◽

Malignant Potential ◽

Uncertain Malignant Potential ◽

Uterine Smooth Muscle ◽

Smooth Muscle Tumors

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Genomic and Epigenomic Profile of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) Revealed Similarities and Differences with Leiomyomas and Leiomyosarcomas

International Journal of Molecular Sciences ◽

10.3390/ijms22041580 ◽

2021 ◽

Vol 22 (4) ◽

pp. 1580

Author(s):

Donatella Conconi ◽

Serena Redaelli ◽

Andrea Lissoni ◽

Chiara Cilibrasi ◽

Patrizia Perego ◽

...

Keyword(s):

Smooth Muscle ◽

Prognostic Markers ◽

Array Cgh ◽

Malignant Potential ◽

Cancer Genes ◽

Uncertain Malignant Potential ◽

Uterine Smooth Muscle ◽

Smooth Muscle Tumors ◽

Similarities And Differences ◽

Definition Of

Uterine smooth muscle tumors of uncertain malignant potential (STUMPs) represent a heterogeneous group of tumors that cannot be histologically diagnosed as unequivocally benign or malignant. For this reason, many authors are working to obtain a better definition of diagnostic and prognostic criteria. In this work, we analyzed the genomic and epigenomic profile of uterine smooth muscle tumors (USMTs) in order to find similarities and differences between STUMPs, leiomyosarcomas (LMSs) and leiomyomas (LMs), and possibly identify prognostic factors in this group of tumors. Array-CGH data on 23 USMTs demonstrated the presence of a more similar genomic profile between STUMPs and LMSs. Some genes, such as PRKDC and PUM2, with a potential prognostic value, were never previously associated with STUMP. The methylation data appears to be very promising, especially with regards to the divergent profile found in the sample that relapsed, characterized by an overall CGI hypomethylation. Finally, the Gene Ontology analysis highlighted some cancer genes that could play a pivotal role in the unexpected aggressive behavior that can be found in some of these tumors. These genes could prove to be prognostic markers in the future.

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