scholarly journals Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion

2018 ◽  
Vol 130 ◽  
pp. 290-295 ◽  
Author(s):  
Matthias Manne Knopp ◽  
Johan Wendelboe ◽  
René Holm ◽  
Thomas Rades
Keyword(s):  
Phase Separation ◽  
Amorphous Phase ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion

scholarly journals Preparation and Characterization of Spherical Amorphous Solid Dispersion with Amphotericin B

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 235 ◽  
Author(s):  
Lyes Mehenni ◽  
Malika Lahiani-Skiba ◽  
Guy Ladam ◽  
François Hallouard ◽  
Mohamed Skiba
Keyword(s):  
Amphotericin B ◽  
Solid Dispersion ◽  
In Vitro Release ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Scanning Calorimetry ◽  
New Generation ◽  
Powder Aerosols

In the present study, new polymer microspheres of amphotericin B (AmB) were prepared by a spray drying technique using cyclodextrin polymers (Poly-CD) to improve the solubility and dissolution of AmB, to prevent in vivo toxic AmB aggregations. Formulations were characterized through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermal analysis, Raman spectroscopy, particle size, drug purity test and in vitro release studies. The analysis indicated that the chemical structure of AmB remained unchanged in the amorphous solid dispersion, but the structure was changed from crystalline to amorphous. AmB was completely release from such optimized formulations in dissolution media in 40 min. This work may contribute to a new generation of spherical amorphous solid dispersion using a cyclodextrin polymer, which has implications for the possibility of drug development for oral utilization or as powder aerosols for pulmonary administration.

Generation of a Weakly Acidic Amorphous Solid Dispersion of the Weak Base Ritonavir with Equivalent In Vitro and In Vivo Performance to Norvir Tablet

2018 ◽  
Vol 19 (5) ◽  
pp. 1985-1997 ◽  
Author(s):  
Daniel J. Ellenberger ◽  
Dave A. Miller ◽  
Sandra U. Kucera ◽  
Robert O. Williams
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Weak Base

Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier

2017 ◽  
Vol 531 (1) ◽  
pp. 324-331 ◽  
Author(s):  
Johan Wendelboe ◽  
Matthias Manne Knopp ◽  
Fauzan Khan ◽  
Nabil Chourak ◽  
Thomas Rades ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Ph Sensitive ◽  
In Vitro Dissolution ◽  
Amorphous Solid Dispersion

In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy

2009 ◽  
Vol 138 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Satomi Onoue ◽  
Hideyuki Sato ◽  
Yohei Kawabata ◽  
Takahiro Mizumoto ◽  
Naofumi Hashimoto ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Cyclosporine A ◽  
Amorphous Solid ◽  
Inhalation Therapy ◽  
Amorphous Solid Dispersion ◽  
In Vivo Characterization
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