scholarly journals Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery

2020 ◽  
Vol 152 ◽  
pp. 10-17 ◽  
Author(s):  
Ruba Ismail ◽  
Thi Nhu Quynh Phan ◽  
Flavia Laffleur ◽  
Ildikó Csóka ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Oral Delivery ◽  
Ion Pairing ◽  
Lipid Nanocarriers ◽  
Hydrophobic Ion Pairing

Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment

2016 ◽  
Vol 14 (8) ◽  
pp. 983-995 ◽  
Author(s):  
Mariana Silva Oliveira ◽  
Gisele Castro Assis Goulart ◽  
Lucas Antônio Miranda Ferreira ◽  
Guilherme Carneiro
Keyword(s):  
Cancer Treatment ◽  
Ion Pairing ◽  
Drug Encapsulation ◽  
Lipid Nanocarriers ◽  
Hydrophobic Ion Pairing

Hydrophobic Ion Pairing of Peptide Antibiotics for Processing into Controlled Release Nanocarrier Formulations

2017 ◽  
Vol 15 (1) ◽  
pp. 216-225 ◽  
Author(s):  
Hoang D. Lu ◽  
Paradorn Rummaneethorn ◽  
Kurt D. Ristroph ◽  
Robert K. Prud’homme
Keyword(s):  
Controlled Release ◽  
Ion Pairing ◽  
Peptide Antibiotics ◽  
Hydrophobic Ion Pairing

Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis

2021 ◽  
Vol 17 (6) ◽  
pp. 1199-1207
Author(s):  
Hanmei Li ◽  
Hongyi Zhuo ◽  
Dan Yin ◽  
Wei Li ◽  
Yamei Zhang ◽  
...  
Keyword(s):  
Particle Size ◽  
Medicinal Plant ◽  
Treatment Effect ◽  
Retention Time ◽  
Therapeutic Efficacy ◽  
Ion Pairing ◽  
Systemic Toxicity ◽  
Joint Cavity ◽  
Hydrophobic Ion Pairing ◽  
Chinese Medicinal Plant

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.

Novel skin penetrating berberine oleate complex capitalizing on hydrophobic ion pairing approach

2018 ◽  
Vol 549 (1-2) ◽  
pp. 76-86 ◽  
Author(s):  
Abrar S. Torky ◽  
May S. Freag ◽  
Maha M.A. Nasra ◽  
Ossama Y. Abdallah
Keyword(s):  
Ion Pairing ◽  
Hydrophobic Ion Pairing

Improved potency of cisplatin by hydrophobic ion pairing

2004 ◽  
Vol 54 (5) ◽  
pp. 441-448 ◽  
Author(s):  
Lixin Feng ◽  
Alexandra De Dille ◽  
Vicky J. Jameson ◽  
Leia Smith ◽  
William S. Dernell ◽  
...  
Keyword(s):  
Ion Pairing ◽  
Hydrophobic Ion Pairing

scholarly journals Lipid-based nanocarriers for oral delivery of peptides

OCL ◽  
2022 ◽  
Vol 29 ◽  
pp. 1
Author(s):  
Camille Dumont
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Intestinal Transport ◽  
Intestinal Lumen ◽  
Burst Release ◽  
Solid Lipid ◽  
Lipid Nanocarriers ◽  
Therapeutic Peptides ◽  
Poor Stability ◽  
Platelet Shape

Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border. We have evaluated the capacity of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) to overcome both oral bioavailability limiting aspects, using leuprolide (LEU) as model peptide. Lipidization of LEU by formation of a hydrophobic ion pair (HIP) with sodium docusate enables a significant increase of peptide encapsulation efficiency in both SLN and NLC. The nanocarriers, obtained by high-pressure homogenization, measured 120 nm and were platelet shaped. Regarding the protective effect towards proteolytic degradation, only NLC maintained LEU integrity in presence of trypsin. Intestinal transport, evaluated on Caco-2 (enterocyte-like model) and Caco-2/HT29-MTX (mucin-secreting model) monolayers, showed nanocarriers internalization by enterocytes but no improvement of LEU permeability. Indeed, the combination of nanoparticles platelet-shape with the poor stability of the HIP in the transport medium induces a high burst release of the peptide, limiting nanoparticles capacity to transport LEU across the intestinal border. Stability of peptide lipidization needs to be improved to withstand biorelevant medium to benefit from the advantages of encapsulation in solid lipid nanocarriers and consequently improve their oral bioavailability.

scholarly journals Hydrophobic ion pairing (HIP) of (poly)peptide drugs: Benefits and drawbacks of different preparation methods

2020 ◽  
Vol 151 ◽  
pp. 73-80 ◽  
Author(s):  
Richard Wibel ◽  
Julian David Friedl ◽  
Sergey Zaichik ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Ion Pairing ◽  
Peptide Drugs ◽  
Preparation Methods ◽  
Hydrophobic Ion Pairing
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