Hypoglycaemic effect of quinolizidine alkaloids — lupanine and 2-thionosparteine on non-diabetic and streptozotocin-induced diabetic rats

AbstractBackground:In continuation of our study of the biological activity of the aqueous extract ofMethods:Thirty male albino Wistar rats (150−200 g) were weight-matched into six groups of five rats each. Groups 1 and 2 were the normal (non-induced) and toxic (alloxan-induced) controls, respectively. Groups 3−6 were induced and treated with 1, 2 and 3 g/kg of the aqueous extract ofResults:There was a significant reduction in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin triglyceride, creatinine, urea and electrolyte when compared with toxic control group. The liver marker enzymes were restored in all the treated groups. The aqueous stem extract possessed hypoglycaemic effect and reversed the histopathological damage in alloxan-induced diabetic rats.Conclusions:This study suggests that aqueous stem extract of

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Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

Revista Brasileira de Farmacognosia ◽

10.1590/s0102-695x2007000200005 ◽

2007 ◽

Vol 17 (2) ◽

pp. 166-169 ◽

Cited By ~ 10

Author(s):

Fatima Torrico ◽

Mariana Cepeda ◽

Geraldine Guerrero ◽

Fidel Melendez ◽

Zuleima Blanco ◽

...

Keyword(s):

Diabetic Rats ◽

Hypoglycaemic Effect

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Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

Egyptian Journal of Radiation Sciences and Applications ◽

10.21608/ejrsa.2011.1480 ◽

2011 ◽

Vol 24 (2) ◽

pp. 345-358

Keyword(s):

Diabetic Rats ◽

Hypoglycaemic Effect ◽

Clove Extract

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Comparative Study of Hypoglycaemic Effect of Crude Nigella Sativa Linn (Kalajira) and Its Ethanol Extract on STZ Induced Diabetic Rats

Journal of Medical Science & Research ◽

10.47648/jmsr.2005.v0502.05 ◽

2005 ◽

Vol 5 (Number 2) ◽

pp. 27-32

Author(s):

N Uddin ◽

Z F Dewan ◽

M Nasir ◽

M Zaman ◽

R R Saha

Keyword(s):

Comparative Study ◽

Nigella Sativa ◽

Ethanol Extract ◽

Diabetic Rats ◽

Hypoglycaemic Effect

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Preliminary Evaluation of Methanol Extract of Aframomum melegueta seed for Hypoglycaemic Effect in Rats

Journal of Veterinary and Biomedical Sciences ◽

10.36108/jvbs/8102.10.0120 ◽

2018 ◽

Vol 1 (1) ◽

pp. 11-18

Author(s):

H. M. Olaitan

Keyword(s):

Blood Glucose ◽

Methanol Extract ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Seed Extract ◽

Albino Rats ◽

Preliminary Evaluation ◽

Hypoglycaemic Effect ◽

Group I ◽

Significant Difference

Diabetes is a metabolic disease that has caused severe health complications and premature deaths in both developed and developing countries. It is characterized by hyperglycaemia. This study was designed to investigate the hypoglycaemic effect of methanol extract of Aframomum melegueta seed in Alloxan-induced diabetic rats. Adult albino rats of either sex weighing between 90 – 150 g were used. Diabetes was induced by administration of alloxan (100 mg/kg i.p). The rats were seperated into 5 groups of five rats each. Group I served as the negative control and was given normal saline (10 ml/kg p.o). Groups II – IV were given A. melegueta extract at varying doses of 100, 200 and 400 mg/kg p.o respectively. Group V was treated with Glibenclamide at a dose of 2 mg/kg p.o to serve as the positive control. The various treatments were administered for a period of 14 days. The Fasting Blood Glucose (FBG) levels of the rats were determined before and weekly after commencement of treatment with the aid of a glucometer using blood collected from the tail vein. Result revealed that there was a significant (p<0.05) reduction of the Fasting Blood Glucose level after 14 days of treatment in the diabetic groups as compared to the FBG before the treatment. However, there was no significant difference (p>0.05) in the mean Fasting Blood Glucose levels between groups treated with varying doses of A. melegueta seed extract. Also, there was no significant difference (p>0.05) between groups treated with A. melegueta extract and the group treated with Glibenclamide. The investigation showed that A. melegueta seed extract had hypoglycaemic effect in Alloxan – induced diabetic rats which was comparable with that of Glibenclamide, a conventionally used hypoglycaemic drug. However, the hypoglycaemic effect of the extract was not dose dependent. This therefore suggests that Aframomum melegueta seed has a useful potential for the treatment of diabetes mellitus due to its hypoglycaemic effect.

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