Development of a simple method for the preparation of a silica gel based controlled delivery system with a high drug content

Purpose: The purpose of this study was to compare pain, efficacy and postoperative complications of anesthesia in first primary mandibular molars anesthetized with either intraligamentary (IL) or supraperiosteal (SP) anesthesia using a computer-controlled delivery system (CCDS). Study design: This randomized, controlled-crossover, blind clinical trial was conducted with 90 children requiring bilateral extraction, pulpotomy or restorative treatment of first mandibular primary molars. A CCDS was used to deliver IL anesthesia to 1 deciduous tooth and SP anesthesia to the contralateral tooth in each patient. Severity of pain and efficacy of anesthesia during the treatments were evaluated using the Wong-Baker Faces Pain Rating Scale (PRS) and comfort and side effects were assessed using post-injection and post-treatment questionnaires. Data were analyzed using χ2 and Mann-Whitney U tests. Results: According to PRS scores, pain levels during extraction were significantly higher with IL when compared to SP. Patients reported significantly less pain during needle insertion with SP when compared to IL; however, rates of postoperative complications were significantly higher with SP when compared to IL. Conclusions: CCDS-administered IL anesthesia and SP anesthesia were similarly effective when used during restorative treatment and pulpotomy of primary mandibular molars; however, SP was more effective than IL when used during extraction procedures.

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In Vitro Effects of a Chlorhexidine Controlled Delivery System

Artificial Organs ◽

10.1046/j.1525-1594.2003.07245.x ◽

2003 ◽

Vol 27 (5) ◽

pp. 486-491 ◽

Cited By ~ 10

Author(s):

Carolina Ferreira Franco ◽

André Luiz Pataro ◽

Leandra Cristina Ribeiro E Souza ◽

Vagner Rodrigues Santos ◽

María Esperanza Cortés ◽

...

Keyword(s):

Delivery System ◽

Controlled Delivery ◽

In Vitro Effects

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CRIPDOM CONTROLLED DELIVERY SYSTEM FOR ASPIRIN

Advances in Drug Delivery Systems, 6 ◽

10.1016/b978-0-444-82027-3.50058-4 ◽

1994 ◽

pp. 327-328

Author(s):

V. Azuree ◽

J P Selles

Keyword(s):

Delivery System ◽

Controlled Delivery

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Dental anaesthesia for children – effects of a computer-controlled delivery system on pain and heart rate: a randomised clinical trial

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.bjoms.2018.08.006 ◽

2018 ◽

Vol 56 (8) ◽

pp. 744-749 ◽

Cited By ~ 8

Author(s):

R. Patini ◽

E. Staderini ◽

M. Cantiani ◽

A. Camodeca ◽

F. Guglielmi ◽

...

Keyword(s):

Clinical Trial ◽

Heart Rate ◽

Delivery System ◽

Randomised Clinical Trial ◽

Controlled Delivery ◽

Computer Controlled

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Determination of Benzo (a) pyrene in Foods

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/61.1.129 ◽

1978 ◽

Vol 61 (1) ◽

pp. 129-135

Author(s):

Yukio Saito ◽

Hiroshi Sekita ◽

Mitsuharu Takeda ◽

Mitsuru Uchiyama

Keyword(s):

Sulfuric Acid ◽

Silica Gel ◽

Column Chromatography ◽

Analytical Method ◽

Selective Extraction ◽

Acid Extraction ◽

Simple Method ◽

Extraction Step ◽

Concentrated Sulfuric Acid

Abstract An analytical method was developed for determining benzo (a) pyrene in foods, suitable for routine use. The method consists of 4 cleanup steps: (1) alkali cleavage of sample, (2) preliminary silica gel column chromatography, (3) selective extraction with concentrated sulfuric acid, and (4) further silica gel column chromatography. Recoveries of benzo- (a) pyrene added to 50 g (or 10 g) food at levels of 0.4 ppb (or 2 ppb) ranged from 70% for short-necked clam and mackerel to 85% for chicken meat. The sulfuric acid extraction step affords a simple method for isolating benzo (a)- pyrene from various kinds of interfering substances which could not be separated by existing methods.

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