In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

2012 ◽  
Vol 45 (3) ◽  
pp. 235-250 ◽  
Author(s):  
Stephen T. Buckley ◽  
Sarah M. Fischer ◽  
Gert Fricker ◽  
Martin Brandl
Keyword(s):  
In Vitro Models ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells

2017 ◽  
Vol 518 (1-2) ◽  
pp. 29-40 ◽  
Author(s):  
Kalle Sigfridsson ◽  
Urban Skantze ◽  
Pia Skantze ◽  
Svante Johansson ◽  
Iain Grant ◽  
...  
Keyword(s):  
Liver Cells ◽  
In Vitro Characterization ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

scholarly journals FABRICATION AND IN VITRO CHARACTERIZATION OF A NOVEL NANOSUSPENSION OF TELMISARTAN: A POORLY SOLUBLE DRUG PREPARED BY ANTISOLVENT PRECIPITATION TECHNIQUE USING 33 FACTORIAL DESIGN

2020 ◽  
pp. 286-294
Author(s):  
PRASANTA KUMAR MOHAPATRA ◽  
SIREESHA ◽  
VAIBHAV RATHORE ◽  
HARISH CHANDRA VERMA ◽  
BIBHUTI PRASAD RATH ◽  
...  
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Zeta Potential ◽  
Dissolution Rate ◽  
Release Kinetics ◽  
Precipitation Method ◽  
Lauryl Sulfate ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Objective: The motivation behind the current examination was to build the solvency and dissolution rate of an antihypertensive drug telmisartan by the planning of nanosuspension by precipitation method at the research facility scale. We researched the nanoparticle manufacture of telmisartan employing a 33 factorial experimental configuration considering the impacts of nanosuspension on the physical, morphological, and dissolution properties of telmisartan. Methods: To get ready, nanosuspension particles of an ineffectively dissolvable drug are moreover of a drug solution to the anti-solvent leads to abrupt supersaturation and precipitation the making of nanoparticles. The nanosuspension particles of a poorly soluble drug loaded with urea and surfactants (sodium lauryl sulfate (SLS), poloxamer 188, Tween 80) have been prepared by a precipitation method. The nanosuspension particles were characterized for particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), in vitro drug release, and release kinetics. Results: The readily optimized batch nanosuspension particles evaluated and exhibited the particle size (750 nm), zeta potential (-24.33 mV), differential scanning calorimetry (DSC) drug exhibited a change in crystalline form to amorphous, in vitro dissolution (F12 was higher 95% within 5 min) and drug release kinetics. The formulation parameter of surfactant concentration is optimized. Conclusion: The formulation of the nanosuspension approach has been shown to substantial improvement in the dissolution rate, thereby enhancing the oral bioavailability with the future development of this technology.

scholarly journals Development and Validation of a Discriminating In Vitro Dissolution Method for a Poorly Soluble Drug, Olmesartan Medoxomil: Comparison Between Commercial Tablets

2010 ◽  
Vol 11 (2) ◽  
pp. 637-644 ◽  
Author(s):  
Lisiane Bajerski ◽  
Rochele Cassanta Rossi ◽  
Carolina Lupi Dias ◽  
Ana Maria Bergold ◽  
Pedro Eduardo Fröehlich
Keyword(s):  
Olmesartan Medoxomil ◽  
In Vitro Dissolution ◽  
Dissolution Method ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Development And Validation

Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model poorly soluble drug

2020 ◽  
Vol 146 ◽  
pp. 105262 ◽  
Author(s):  
Rui Peng ◽  
Jiahao Huang ◽  
Li He ◽  
Lina Zhao ◽  
Cuitong Wang ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Intraorally fast-dissolving particles of a poorly soluble drug: Preparation and in vitro characterization

2009 ◽  
Vol 71 (2) ◽  
pp. 271-281 ◽  
Author(s):  
Riikka Laitinen ◽  
Eero Suihko ◽  
Kaisa Toukola ◽  
Mikko Björkqvist ◽  
Joakim Riikonen ◽  
...  
Keyword(s):  
Drug Preparation ◽  
In Vitro Characterization ◽  
Poorly Soluble ◽  
Poorly Soluble Drug
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