Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

Amino Acid Transporter ◽

Pharmacophore Modeling ◽

Activity Relationship ◽

Structure Activity ◽

Identification and Structure–Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00447 ◽

2019 ◽

Vol 10 (10) ◽

pp. 4414-4429

Author(s):

Peng Wu ◽

Walden E. Bjørn-Yoshimoto ◽

Markus Staudt ◽

Anders A. Jensen ◽

Lennart Bunch

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Selective Inhibitors ◽

Excitatory Amino Acid Transporter ◽

Structure Activity ◽

Relationship Study ◽

Subtype 3

Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

Journal of Medicinal Chemistry ◽

10.1021/jm1009154 ◽

2010 ◽

Vol 53 (19) ◽

pp. 7180-7191 ◽

Cited By ~ 82

Author(s):

Mette N. Erichsen ◽

Tri H. V. Huynh ◽

Bjarke Abrahamsen ◽

Jesper F. Bastlund ◽

Christoffer Bundgaard ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Selective Inhibitor ◽

Activity Relationship ◽

Excitatory Amino Acid Transporter ◽

Structure Activity ◽

Relationship Study ◽

Acid Transporter

Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure–Activity Relationship Study

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01058 ◽

2016 ◽

Vol 59 (19) ◽

pp. 8757-8770 ◽

Cited By ~ 11

Author(s):

Stinne W. Hansen ◽

Mette N. Erichsen ◽

Bingru Fu ◽

Walden E. Bjørn-Yoshimoto ◽

Bjarke Abrahamsen ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Excitatory Amino Acid Transporter ◽

New Class ◽

Structure Activity ◽

Relationship Study ◽

Acid Transporter

Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2003.10.004 ◽

2004 ◽

Vol 39 (1) ◽

pp. 59-67 ◽

Cited By ~ 75

Author(s):

Apurba K. Bhattacharjee ◽

Mark G. Hartell ◽

Daniel A. Nichols ◽

Rickey P. Hicks ◽

Benjamin Stanton ◽

...

Keyword(s):

Three Dimensional ◽

Pharmacophore Modeling ◽

Activity Relationship ◽

Structure Activity ◽

Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2018.04.002 ◽

2018 ◽

Vol 28 (10) ◽

pp. 1874-1878 ◽

Cited By ~ 2

Author(s):

Jianfeng Mou ◽

Songliang Wu ◽

Zhi Luo ◽

Fengying Guo ◽

Haiying He ◽

...

Keyword(s):

Liver Disease ◽

Amino Acid ◽

Activity Relationship ◽

Cholestatic Liver Disease ◽

Acid Moiety ◽

Caspase Inhibitors ◽

Structure Activity ◽

Amino Acid Moiety ◽

Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism

SpringerPlus ◽

10.1186/2193-1801-2-112 ◽

2013 ◽

Vol 2 (1) ◽

pp. 112

Author(s):

Tri HV Huynh ◽

Charles S Demmer ◽

Bjarke Abrahamsen ◽

Emil Marcher ◽

Mikael Frykman ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Activity Relationship ◽

Amino Acid Transporters ◽

Excitatory Amino Acid Transporters ◽

Structure Activity ◽

Relationship Study ◽

Potential Inhibitors

Three-dimensional quantitative structure–activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1)

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.08.058 ◽

2011 ◽

Vol 19 (21) ◽

pp. 6409-6418 ◽

Cited By ~ 7

Author(s):

Iris Thondorf ◽

Valerie Voigt ◽

Sarah Schäfer ◽

Sabine Gebauer ◽

Katja Zebisch ◽

...

Keyword(s):

Amino Acid ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

Acid Transporter

Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2

Journal of Medicinal Chemistry ◽

10.1021/jm501086v ◽

2014 ◽

Vol 57 (22) ◽

pp. 9473-9479 ◽

Cited By ~ 11

Author(s):

Serena Cuboni ◽

Christian Devigny ◽

Bastiaan Hoogeland ◽

Andrea Strasser ◽

Sebastian Pomplun ◽

...

Keyword(s):

Amino Acid ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Structure Activity ◽

Acid Transporter ◽

Relationship Of

Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids

Organic & Biomolecular Chemistry ◽

10.1039/b908286g ◽

2009 ◽

Vol 7 (18) ◽

pp. 3805 ◽

Cited By ~ 12

Author(s):

Tomohiro Tanaka ◽

Wataru Nomura ◽

Tetsuo Narumi ◽

Ai Esaka ◽

Shinya Oishi ◽

...

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Aromatic Amino Acids ◽

Activity Relationship ◽

Amino Acid Residues ◽

Structure Activity ◽

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

Journal of Pharmacological Sciences ◽

10.1016/j.jphs.2017.01.006 ◽

2017 ◽

Vol 133 (2) ◽

pp. 96-102 ◽

Cited By ~ 31

Author(s):

Pornparn Kongpracha ◽

Shushi Nagamori ◽

Pattama Wiriyasermkul ◽

Yoko Tanaka ◽

Kazuko Kaneda ◽

...

Keyword(s):

Amino Acid ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Cancer Type ◽

Structure Activity ◽

Acid Transporter ◽

Relationship Of