Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability

2018 ◽  
Vol 112 ◽  
pp. 28-37 ◽  
Author(s):  
Luíse L. Chaves ◽  
Sofia A. Costa Lima ◽  
Alexandre C.C. Vieira ◽  
Luísa Barreiros ◽  
Marcela A. Segundo ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Oral Delivery ◽  
Plga Nanoparticles ◽  
Formulation Variables

scholarly journals Effect of Chitosan Coating on PLGA Nanoparticles for Oral Delivery of Thymoquinone: In Vitro, Ex Vivo, and Cancer Cell Line Assessments

Coatings ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Sultan Alshehri ◽  
Syed Sarim Imam ◽  
Md Rizwanullah ◽  
Khalid Umar Fakhri ◽  
Mohd Moshahid Alam Rizvi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Particle Size ◽  
Oral Delivery ◽  
Ex Vivo ◽  
Cancer Cell Line ◽  
Entrapment Efficiency ◽  
Plga Nanoparticles ◽  
Cancer Management ◽  
Mcf 7

In the present study, thymoquinone (TQ)-encapsulated chitosan- (CS)-coated poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were formulated using the emulsion evaporation method. NPs were optimized by using 33-QbD approach for improved efficacy against breast cancer. The optimized thymoquinone loaded chitosan coated Poly (d,l-lactide-co-glycolide) nanoparticles (TQ-CS-PLGA-NPs) were successfully characterized by different in vitro and ex vivo experiments as well as evaluated for cytotoxicity in MDA-MB-231 and MCF-7 cell lines. The surface coating of PLGA-NPs was completed by CS coating and there were no significant changes in particle size and entrapment efficiency (EE) observed. The developed TQ-CS-PLGA-NPs showed particle size, polydispersibility index (PDI), and %EE in the range between 126.03–196.71 nm, 0.118–0.205, and 62.75%–92.17%. The high and prolonged TQ release rate was achieved from TQ-PLGA-NPs and TQ-CS-PLGA-NPs. The optimized TQ-CS-PLGA-NPs showed significantly higher mucoadhesion and intestinal permeation compared to uncoated TQ-PLGA-NPs and TQ suspension. Furthermore, TQ-CS-PLGA-NPs showed statistically enhanced antioxidant potential and cytotoxicity against MDA-MB-231 and MCF-7 cells compared to uncoated TQ-PLGA-NPs and pure TQ. On the basis of the above findings, it may be stated that chitosan-coated TQ-PLGA-NPs represent a great potential for breast cancer management.

scholarly journals Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

2019 ◽  
Vol 4 (1) ◽  
pp. 84-96 ◽  
Author(s):  
Nicholas G. Lamson ◽  
Adrian Berger ◽  
Katherine C. Fein ◽  
Kathryn A. Whitehead
Keyword(s):  
Intestinal Permeability ◽  
Oral Delivery

scholarly journals Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid

2018 ◽  
Vol 46 (sup2) ◽  
pp. 993-1002 ◽  
Author(s):  
Isabela Angeli de Lima ◽  
Najeh Maissar Khalil ◽  
Tania Toyomi Tominaga ◽  
Anna Lechanteur ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Oral Delivery ◽  
Plga Nanoparticles

scholarly journals Pharmacodynamics and Pharmacokinetics Evaluation of Ranitidine Microemulsion on Experimental Animals

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Sajal Kumar Jha ◽  
Roopa Karki ◽  
Venkatesh Dinnekere Puttegowda ◽  
Amitava Ghosh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intestinal Permeability ◽  
Delivery System ◽  
Oral Delivery ◽  
Tween 80 ◽  
Standard Drug ◽  
Alternative Drug ◽  
And Control ◽  
Antiulcer Therapy

Ranitidine microemulsion was investigated for its pharmacodynamic and pharmacokinetic evaluation to find out the suitability of microemulsion as a potential drug delivery system in the treatment of ulcer. The bioavailability of ranitidine after oral administration is about 50% and is absorbed via the small intestine; this may be due to low intestinal permeability. Hence the aim of present investigation was to maximize the therapeutic efficacy of ranitidine by developing microemulsion to increase the intestinal permeability as well as bioavailability. A ground nut oil based microemulsion formulation with Tween-80 as surfactant and PEG-400 as cosurfactant was developed for oral delivery of ranitidine and characterized for physicochemical parameters. In pharmacodynamic studies, significant (P<0.05) variation in parameters estimated was found between the treated and control groups. Ranitidine microemulsion exhibited higher absorption and Cmax (863.20 ng·h/mL) than the standard (442.20 ng/mL). It was found that AUC0–24 hr obtained from the optimized ranitidine test formulation (5426.5 ng·h/mL) was significantly higher than the standard ranitidine (3920.4 ng·h/mL). The bioavailability of optimized formulation was about 1.4-fold higher than that of standard drug. This enhanced bioavailability of ranitidine microemulsion may be used as an effective and alternative drug delivery system for the antiulcer therapy.

Synthesis of CSK-DEX-PLGA Nanoparticles for the Oral Delivery of Exenatide to Improve Its Mucus Penetration and Intestinal Absorption

2019 ◽  
Vol 16 (2) ◽  
pp. 518-532 ◽  
Author(s):  
Yina Song ◽  
Yanan Shi ◽  
Liping Zhang ◽  
Haiyan Hu ◽  
Chunyan Zhang ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Oral Delivery ◽  
Plga Nanoparticles ◽  
Mucus Penetration
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