Drug delivery to solid tumors with heterogeneous microvascular networks: Novel insights from image-based numerical modeling

2020 ◽  
Vol 151 ◽  
pp. 105399
Author(s):  
Farshad Moradi Kashkooli ◽  
M. Soltani ◽  
Mohammad-Hossein Hamedi
Keyword(s):  
Drug Delivery ◽  
Numerical Modeling ◽  
Solid Tumors ◽  
Microvascular Networks

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble-Mediated Drug Delivery

Langmuir ◽  
2018 ◽  
Vol 35 (31) ◽  
pp. 10128-10138 ◽  
Author(s):  
Eric K. Juang ◽  
Ine De Cock ◽  
Christina Keravnou ◽  
Madison K. Gallagher ◽  
Sara B. Keller ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Microvascular Networks

scholarly journals Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors

2019 ◽  
Vol 144 ◽  
pp. 16-34 ◽  
Author(s):  
Brianna Cote ◽  
Deepa Rao ◽  
Raid G. Alany ◽  
Glen S. Kwon ◽  
Adam W.G. Alani
Keyword(s):  
Drug Delivery ◽  
Solid Tumors
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