scholarly journals Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients

2022 ◽  
Vol 44 (2) ◽  
pp. 133-138
Author(s):  
Hala I. Elgendy ◽  
Mohammed Y. Ezzeldin ◽  
Yumn A. Elsabagh
Keyword(s):  
Systemic Sclerosis ◽  
Systemic Inflammation ◽  
Musculoskeletal Ultrasound

Exercise in systemic sclerosis intensifies systemic inflammation and oxidative stress

2010 ◽  
Vol 39 (1) ◽  
pp. 63-70 ◽  
Author(s):  
H Harðardóttir ◽  
HAC van Helvoort ◽  
MC Vonk ◽  
FHJ van den Hoogen ◽  
PNR Dekhuijzen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systemic Sclerosis ◽  
Systemic Inflammation ◽  
And Oxidative Stress

scholarly journals Development of a Musculoskeletal Ultrasound Protocol to Examine Upper Extremity Rehabilitation Outcomes in Systemic Sclerosis

2020 ◽  
Vol 37 (1) ◽  
pp. 13-23
Author(s):  
Susan L. Murphy ◽  
Donnamarie Krause ◽  
Shawn C. Roll ◽  
Girish Gandikota ◽  
Mary Barber ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Interrater Reliability ◽  
Outcome Measurement ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Thickness Measurement ◽  
Musculoskeletal Ultrasound ◽  
Gray Scale ◽  
Strain Elastography ◽  
Rehabilitation Outcomes

Objectives: This study developed a musculoskeletal ultrasound (MSUS) protocol to evaluate rehabilitation outcomes in systemic sclerosis. Materials and Methods: Three MSUS methods (gray-scale, Doppler, strain elastography) and two acquisition techniques (long- vs short-axis; transducer on skin vs floating on gel) were examined in the forearm before and after rehabilitation treatment. For gray-scale, tissue thickness measures and intrarater and interrater reliability were calculated (intraclass correlation coefficients [ICCs]), and paired t tests examined differences among techniques. Results: Five people with diffuse cutaneous systemic sclerosis participated. The most valid and reliable gray-scale technique was with the transducer in long-axis, floating on gel. Doppler and strain elastography did not detect changes. Both dermal and subcutaneous thickness measurement error was small; intrarater and interrater reliability was good to excellent. Preliminary data indicate that treatment may lead to dermal thinning. Conclusion: A replicable protocol was established and may be an adjunct to rehabilitation outcome measurement in systemic sclerosis.

scholarly journals Reliability and Validity of the Tender and Swollen Joint Counts and the Modified Rodnan Skin Score in Early Diffuse Cutaneous Systemic Sclerosis: Analysis from the Prospective Registry of Early Systemic Sclerosis Cohort

2017 ◽  
Vol 44 (6) ◽  
pp. 791-794 ◽  
Author(s):  
Jessica K. Gordon ◽  
Gandikota Girish ◽  
Veronica J. Berrocal ◽  
Meng Zhang ◽  
Christopher Hatzis ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Content Validity ◽  
Reliability And Validity ◽  
Intraobserver Reliability ◽  
Musculoskeletal Ultrasound ◽  
Skin Score ◽  
Modified Rodnan Skin Score ◽  
Diffuse Cutaneous Systemic Sclerosis ◽  
Early Systemic Sclerosis

Objective.To determine the inter/intraobserver reliability of the tender and swollen joint counts (TJC, SJC) and the modified Rodnan Skin Score (mRSS) in diffuse cutaneous systemic sclerosis (dcSSc) and to assess content validity of the TJC/SJC.Methods.Ten rheumatologists completed the SJC, TJC, and mRSS on 7 patients. Musculoskeletal ultrasound (MSUS) was performed.Results.Interobserver and intraobserver reliability for the TJC was 0.97 and 0.99, for the SJC was 0.24 and 0.71, and for the mRSS was 0.81 and 0.94, respectively. MSUS abnormalities did not correspond with SJC/TJC.Conclusion.We demonstrate excellent inter- and intraobserver reliability for the mRSS and TJC in dcSSc. However, the SJC and TJC did not correspond to MSUS.

scholarly journals Characteristics of Joint Involvement and Relationships with Systemic Inflammation in Systemic Sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) Database

2010 ◽  
Vol 37 (7) ◽  
pp. 1488-1501 ◽  
Author(s):  
JEROME AVOUAC ◽  
ULRICH WALKER ◽  
ALAN TYNDALL ◽  
ANDRÉ KAHAN ◽  
MARCO MATUCCI-CERINIC ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Systemic Inflammation ◽  
Severe Disease ◽  
Large Population ◽  
Joint Contracture ◽  
Joint Involvement ◽  
Global Evaluation ◽  
Acute Phase Reactants ◽  
Cross Sectional ◽  
Tendon Friction Rubs

Objective.To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc).Methods.This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs.Results.We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable.Conclusion.Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.

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