Long-term oncologic outcomes following anastomotic leak after anterior resection for rectal cancer: Less chemotherapy, more metastases

2018 ◽  
Vol 44 (10) ◽  
pp. e10-e11 ◽  
Author(s):  
M.E. Allaix ◽  
F. Rebecchi ◽  
F. Famiglietti ◽  
S. Arolfo ◽  
M. Morino
Keyword(s):  
Rectal Cancer ◽  
Anastomotic Leak ◽  
Anterior Resection ◽  
Oncologic Outcomes

Long-term oncologic outcomes following anastomotic leak after anterior resection for rectal cancer: does the leak severity matter?

2019 ◽  
Vol 34 (9) ◽  
pp. 4166-4176 ◽  
Author(s):  
Marco Ettore Allaix ◽  
Fabrizio Rebecchi ◽  
Federico Famiglietti ◽  
Simone Arolfo ◽  
Alberto Arezzo ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anastomotic Leak ◽  
Anterior Resection ◽  
Oncologic Outcomes

scholarly journals Long-term oncologic outcomes of laparoscopic low anterior resection of rectal cancer with preservation of the left colic artery

2020 ◽  
Author(s):  
Yuwen Luo ◽  
Rongjiang Li ◽  
Deqing Wu ◽  
Jun Zeng ◽  
Junjiang Wang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Oncologic Outcomes ◽  
Colic Artery ◽  
Left Colic Artery ◽  
Laparoscopic Low Anterior Resection ◽  
The Difference

Abstract Aim To analyze the effect of preserving the left colic artery (LCA) on long-term oncologic outcomes during laparoscopic low anterior resection of rectal cancer. Methods Clinicopathological and follow-up patients undergoing laparoscopic low anterior resection of rectal cancer in general surgery department of Guangdong Provincial People's Hospital from January 2014 to December 2015 were retrospectively collected. According to the difference surgical methods of inferior mesenteric artery (IMA), 159 cases were divided into the LCA preservation group and 225 cases in the LCA non-preservation group. The 5-year rates of overall survival (OS) and disease-free survival (DFS) were compared between two group. Results 384 patients were included in final analysis. Anastomotic leakage occurred in 7 patients (4.4%) in the LCA preservation group and in 16 patients (7.1%) in the LCA non-preservation group. The follow-up rate was 91.2% (145/159) during 5–60 months in LCA preservation group, and 89.8% (202/225) during 5–60 months in the LCA non-preservation group. The number of patients who developed death, local recurrence and metastasis were 59 (37.1%), 13 (8.2%) and 60 (37.7%) in the LCA preservation group, and 86 (38.2%), 20 (8.9%) and 92 (40.9%) in the LCA non-preservation group, without significant differences (all P ༞ 0.05). The 5-year OS and DFS rates were 69.0% and 59.3% in the LCA preservation group, and 68.8% and 55.9% in the LCA non-preservation group, without significant differences (all P ༞ 0.05). After stratification by TNM Stage, the difference on 5-year OS rates and DFS rates of I stage, II stage and III stage in two groups were no significant as well (all P ༞ 0.05). Conclusions The long-term oncologic outcomes of laparoscopic low anterior resection of rectal cancer with preservation of the LCA are comparable with ligation at origin of IMA.

Long-Term Morbidity and Oncologic Outcomes of Laparoscopic-Assisted Anterior Resection for Upper Rectal Cancer

2009 ◽  
Vol 52 (4) ◽  
pp. 558-566 ◽  
Author(s):  
Simon S. M. Ng ◽  
Ka Lau Leung ◽  
Janet F. Y. Lee ◽  
Raymond Y. C. Yiu ◽  
Jimmy C. M. Li ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anterior Resection ◽  
Oncologic Outcomes ◽  
Laparoscopic Assisted

Long-term Oncologic Outcomes of Robotic Low Anterior Resection for Rectal Cancer

2015 ◽  
Vol 261 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Eun Jung Park ◽  
Min Soo Cho ◽  
Se Jin Baek ◽  
Hyuk Hur ◽  
Byung Soh Min ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Oncologic Outcomes

Special Considerations of Anastomotic Leak in Patients with Rectal Cancer

2021 ◽  
Vol 34 (06) ◽  
pp. 426-430
Author(s):  
Christy E. Cauley ◽  
Matthew F. Kalady
Keyword(s):  
Rectal Cancer ◽  
Anastomotic Leak ◽  
Neoadjuvant Treatment ◽  
Bowel Function ◽  
Oncologic Outcomes ◽  
Clinical Staging ◽  
Clinical Implications ◽  
Major Morbidity

AbstractAnastomotic leak in patients with rectal cancer has the potential to cause worse oncologic outcomes in addition to major morbidity and mortality risk of this dreaded complication. Anatomic location of the rectal cancer determines the ability to perform a restorative operation and the height of the anastomosis in relation to the anal canal. Clinical staging dictates the need for neoadjuvant treatment (such as chemotherapy and radiation) which may also contribute to anastomotic leak risk. In addition to oncologic outcomes, anastomotic leak can impact bowel function, the need for permanent stoma, and long-term quality of life. This study will discuss special considerations for anastomotic leak prevention and clinical implications of this complication in patients with rectal cancer.

scholarly journals The assessment of risk factors for long-term survival outcome in ypN0 patients with rectal cancer after neoadjuvant therapy and radical anterior resection

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Marcin Zeman ◽  
Marek Czarnecki ◽  
Ewa Chmielik ◽  
Adam Idasiak ◽  
Władysław Skałba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Neoadjuvant Therapy ◽  
Anterior Resection ◽  
Negative Impact ◽  
Oncologic Outcomes ◽  
Clinicopathological Factors ◽  
Significant Negative Impact

Abstract Background The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients still develop cancer recurrence despite the absence of the above risk factors. The aim of the study was to assess clinicopathological factors influencing long-term oncologic outcomes in ypN0M0 rectal cancer patients after neoadjuvant therapy and radical anterior resection. Methods A retrospective survival analysis was performed on a group of 195 patients. We assessed clinicopathological factors which included tumor regression grade, number of lymph nodes in the specimen, Charlson comorbidity index (CCI), and colorectal anastomotic leakage (AL). Results In the univariate analysis, AL and CCI > 3 had a significant negative impact on disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS). After the division of ALs into early and late ALs, it was found that only patients with late ALs had a significantly worse survival. The multivariate Cox regression analysis showed that CCI > 3 was a significant adverse risk factor for DFS (HR 5.78, 95% CI 2.15–15.51, p < 0.001), DSS (HR 7.25, 95% CI 2.25–23.39, p < 0.001), and OS (HR 3.9, 95% CI 1.72–8.85, p = 0.001). Similarly, late ALs had a significant negative impact on the risk of DFS (HR 5.05, 95% CI 1.97–12.93, p < 0.001), DSS (HR 10.84, 95% CI 3.44–34.18, p < 0.001), and OS (HR 4.3, 95% CI 1.94–9.53, p < 0.001). Conclusions Late AL and CCI > 3 are the factors that may have an impact on long-term oncologic outcomes. The impact of lymph node yield on understaging was not demonstrated.

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