Association of type 2 diabetes mellitus with incidences of microvascular invasion and survival outcomes in hepatitis B virus-related hepatocellular carcinoma after liver resection: A multicenter study

2021 ◽  
Author(s):  
Xiu-Ping Zhang ◽  
Zong-Tao Chai ◽  
Jin-Kai Feng ◽  
Hui-Min Zhu ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepatitis B Virus ◽  
Liver Resection ◽  
Hepatitis B ◽  
Survival Outcomes ◽  
B Virus

scholarly journals Serological and molecular analysis on the relationships between type 2 diabetes mellitus and hepatitis B virus infection

2016 ◽  
Vol 10 (08) ◽  
pp. 837-844 ◽  
Author(s):  
Huijuan Zhu ◽  
Yiying Wang ◽  
Lugang Yu ◽  
Yunfang Xu ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
B Virus ◽  
Genotype C

Introduction: This study aimed to further analyze the associations between type 2 diabetes mellitus (T2DM) and hepatitis B virus (HBV) infection, and to investigate the relationships between T2DM and the mutations within the HBV major hydrophilic region (MHR). Methodology: In this cross-sectional study, 3,377 persons (338 T2DM patients and 3,039 non-diabetics) were randomly selected. HBsAg detection was performed by enzyme-linked immunosorbent assay. The HBV MHR was amplified, sequenced, and analyzed by nested PCR. Results: The seroprevalence of HBsAg was 21.30% in T2DM patients (72/338), which was significantly higher than in non-diabetics (15.53%). Compared to persons without T2DM, the proportion of T2DM patients positive for HBsAg was significantly elevated in males, people > 55 years (p = 0.039), and people with a body mass index (BMI) ≥ 24 kg/m2. Totally, 112 genotype B and 111 genotype C HBV sequences were isolated. No significant difference in HBV genotype distribution was observed between T2DM patients and non-diabetics. Compared to genotype C HBV-infected cases in non-diabetics, the amino acid substitution rates in the MHR were significantly higher in T2DM patients (p = 0.003). Moreover, seven HBV strains with stop codon mutations within the HBV S gene were identified: three from T2DM patients (5.45%) and four from non-diabetics (2.38%). Conclusions: In China, T2DM is significantly associated with chronic HBV infections and genotype C HBV MHR mutations. Being males, > 55 years of age, and ≥ 24 kg/m2 of BMI are the risk factors of HBV infection in T2DM patients.

Comparison of type 2 diabetes mellitus incidence in different phases of hepatitis B virus infection: A meta-analysis

2017 ◽  
Vol 37 (10) ◽  
pp. 1451-1460 ◽  
Author(s):  
Yi Shen ◽  
Sheng Zhang ◽  
Xulin Wang ◽  
Yuanyuan Wang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Meta Analysis ◽  
Hepatitis B Virus Infection ◽  
B Virus

The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients

2008 ◽  
Vol 20 (7) ◽  
pp. 668-673 ◽  
Author(s):  
Mehmet Demir ◽  
Ender Serin ◽  
Savaş Göktürk ◽  
Nevin Akcaer Ozturk ◽  
Sevsen Kulaksizoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B Virus Infection ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B

Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta-analysis

2015 ◽  
Vol 45 (11) ◽  
pp. 1100-1109 ◽  
Author(s):  
Jian Zhang ◽  
Yi Shen ◽  
Hui Cai ◽  
Yan-Mei Liu ◽  
Gang Qin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Meta Analysis ◽  
Hepatitis B Virus Infection ◽  
Infection Status ◽  
B Virus

scholarly journals Prevalence of type 2 diabetes mellitus in Japanese patients with hepatocellular carcinoma

2010 ◽  
Vol 2 (1) ◽  
pp. 81-84 ◽  
Author(s):  
NAOTA TAURA ◽  
TATSUKI ICHIKAWA ◽  
HISAMITSU MIYAAKI ◽  
HIROSHI YATSUHASHI ◽  
HIROMI ISHIBASHI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Japanese Patients
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