Hybrid Management of Tandem Carotid Arterial Stenoses with Contralateral Carotid Occlusion

The cardiovascular effects of graded arterial or venous hemorrhage were evaluated in developing swine (less than or equal to 1 day, 2–5 days, 1 wk, and 2 wk of age) anesthetized with halothane in 50% N2O–50% O2. Serial 5-ml/kg aliquots of arterial or venous blood were removed at 3- to 4-min intervals to a cumulative total of 20 ml/kg. Tachycardia occurred in most animals. Decreases in aortic pressure to arterial, but not to venous, hemorrhage were age dependent. Renal, femoral, and carotid arterial flows decreased with hemorrhage in all animals; the decreases in blood flow did not differ among the three circulations and were not age dependent. Increases in femoral resistance were obtained to both arterial and venous hemorrhage only in the 2-wk-old group. As the degree of hemorrhage was increased, aortic pressure, regional blood flow, and femoral resistance (2 wk olds) responses were larger in magnitude. Aortic pressure in piglets 1-5 days of age could not be restored to within 20% of the prehemorrhage level at a smaller bleeding volume with arterial than with venous hemorrhage. Pressor responses to norepinephrine (0.5 micrograms/kg) and to bilateral common carotid occlusion were still present after 20-ml/kg hemorrhage. These responses indicate the presence of a progressive maturation-related compensation to the stress of arterial but not venous hemorrhage.

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Carotid arterial control of vasopressin secretion in sheep

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1984.247.3.r589 ◽

1984 ◽

Vol 247 (3) ◽

pp. R589-R594 ◽

Cited By ~ 1

Author(s):

C. E. Wood ◽

L. C. Keil ◽

A. M. Rudolph

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Plasma Concentrations ◽

Carotid Occlusion ◽

Arterial Blood ◽

Plasma Vasopressin ◽

Bilateral Carotid Occlusion ◽

Bilateral Carotid ◽

Vasopressin Secretion ◽

Carotid Arterial

The purpose of this study was to test the role of carotid arterial mechanoreceptors in the control of vasopressin secretion in conscious 6- to 7-wk-old lambs. Bilateral carotid occlusion decreased lingual arterial pressure and stimulated reflex increases in heart rate and femoral arterial blood pressure but did not significantly alter plasma concentrations of vasopressin. Acute vagosympathetic blockade, produced by injection of 2% lidocaine onto the vagosympathetic trunks, did not significantly alter heart rate or blood pressure but did stimulate a slow increase in plasma vasopressin concentration, suggesting that afferent vagal fibers tonically inhibit vasopressin secretion. Bilateral carotid occlusion after vagosympathetic blockade stimulated a brisk increase in plasma vasopressin that was larger than the response to vagosympathetic blockade alone. These results suggest that vasopressin secretion in lambs is partially controlled by arterial mechanoreceptors in the carotid sinus and by extracarotid receptors with vagosympathetic afferent fibers.

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Results of ophthalmosonometry and supraorbital photoplethysmography in evaluating carotid arterial stenoses.

Circulation ◽

10.1161/01.cir.60.2.127 ◽

1979 ◽

Vol 60 (2) ◽

pp. 127-131 ◽

Cited By ~ 4

Author(s):

L J Duke ◽

E E Slaymaker ◽

W C Lamberth ◽

C B Wright

Keyword(s):

Arterial Stenoses ◽

Carotid Arterial

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Ability to Use Duplex US to Quantify Internal Carotid Arterial Stenoses: Fact or Fiction?

Radiology ◽

10.1148/radiology.214.1.r00ja27247 ◽

2000 ◽

Vol 214 (1) ◽

pp. 247-252 ◽

Cited By ~ 59

Author(s):

Edward G. Grant ◽

André J. Duerinckx ◽

Suzie M. El Saden ◽

Michelle L. Melany ◽

Gasser M. Hathout ◽

...

Keyword(s):

Internal Carotid ◽

Arterial Stenoses ◽

Carotid Arterial

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Symptomatic vascular complications after vascular closure device use following diagnostic and interventional catheterisation

VASA ◽

10.1024/0301-1526.33.2.78 ◽

2004 ◽

Vol 33 (2) ◽

pp. 78-81 ◽

Cited By ~ 21

Author(s):

Thalhammer ◽

Aschwanden ◽

Jeanneret ◽

Labs ◽

Jäger

Keyword(s):

Current Literature ◽

Vascular Complications ◽

University Hospital ◽

Closure Device ◽

Ultrasound Guided ◽

Vascular Closure Device ◽

Device Use ◽

Arterial Stenoses ◽

The University ◽

Stenotic Lesions

Background: Haemostatic puncture closure devices for rapid and effective hemostasis after arterial catheterisation are a comfortable alternative to manual compression. Implanting a collagen plug against the vessel wall may become responsible for other kind of vascular injuries i.e. thrombotic or stenotic lesions and peripheral embolisation. The aim of this paper is to report our clinically relevant vascular complications after Angio-Seal® and to discuss the results in the light of the current literature. Patients and methods: We report the symptomatic vascular complications in 17 of 7376 patients undergoing diagnostic or therapeutic catheterisation between May 2000 and March 2003 at the University Hospital Basel. Results: Most patients presented with ischaemic symptoms, arterial stenoses or occlusions and thrombotic lesions (n = 14), whereas pseudoaneurysms were extremely rare (n = 3). Most patients with ischaemic lesions underwent vascular surgery and all patients with a pseudoaneurysm were successfully treated by ultrasound-guided compression. Conclusions: Severe vascular complications after Angio-Seal® are rare, consistent with the current literature. There may be a shift from pseudoaneurysms to ischaemic lesions.

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Systemic Effects of ADP-induced Platelet Aggregation and Their Modification by Aspirin and by Pyridinolcarbamate

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649115 ◽

1973 ◽

Vol 30 (01) ◽

pp. 178-190 ◽

Cited By ~ 6

Author(s):

Itsuro Kobayashi ◽

Paul Didisheim

Keyword(s):

Platelet Aggregation ◽

Venous Pressure ◽

Systemic Effects ◽

Central Venous ◽

Platelet Aggregates ◽

Induced Changes ◽

Second Wave ◽

Carotid Arterial ◽

Arterial Po2

SummaryADP, AMP, or ATP was injected rapidly intravenously in rats. ADP injection resulted in the f olio wing transient changes: a drop in platelet count, a rise in central venous pressure, a fall in carotid arterial PO2, bradycardia, arrhythmia, flutter-fibrillation, and arterial hypotension. AMP and ATP produced some of these same effects; but except for hypotension, their frequency and severity Avere much less than those following ADP.Prior intravenous administration of acetylsalicylic acid or pyridinolcarbamate, two inhibitors of the second wave of ADP-induced platelet aggregation in vitro, significantly reduced the frequency and severity of all the above ADP-induced changes except hypotension. These observations suggest that many of the changes (except hypotension) observed to follow ADP injection are produced by platelet aggregates which lodge transiently in various microcirculatory beds then rapidly disaggregate and recirculate.

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Platelet Hyperaggregability in Ischemic Cerebrovascular Disease and Effects of Aspirin

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657237 ◽

1982 ◽

Vol 48 (02) ◽

pp. 117-119 ◽

Cited By ~ 6

Author(s):

M Kusunoki ◽

K Kimura ◽

K Nagatsuka ◽

Y Isaka ◽

O Uyama ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Venous Blood ◽

Second Phase ◽

Cerebral Angiogram ◽

Peripheral Venous Blood ◽

Chronic Stage ◽

Ischemic Cerebrovascular Disease ◽

Carotid Arterial ◽

Platelet Hyperaggregability ◽

The Brain

SummaryPlatelet aggregation was studied in 24 patients in the chronic stage of ischemic cerebrovascular disease (CVD), with cerebral affluent and effluent blood, i.e., carotid arterial and internal jugular venous blood, and also with peripheral venous blood. Aggregation tests were performed at various final concentrations of sodium arachidonate (A.A.) and ADP. In 17 patients, not taking aspirin, platelet aggregability in jugular venous blood was significantly accentuated compared with that in arterial and peripheral venous blood. This tendency was more marked in the patients with cerebral artery stenosis and/or occlusion than in those with normal cerebral angiogram. In 7 patients taking 500 mg or more oral aspirin, aggregation differences across the brain were not observed and A.A. aggregation and the second phase of ADP aggregation were completely suppressed. These results suggest that a prophylactic administration of aspirin may be beneficial for patients in chronic stage of CVD.

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