Single Gene Therapies to Improve the Longevity of Peripheral Bypasses: A Systems Biology - Multiscale Modelling Approach

2020 ◽  
Vol 48 ◽  
pp. 53-54
Author(s):  
Stefano Casarin ◽  
Marc Garbey ◽  
Jared Rozowsky ◽  
Scott Berceli
2020 ◽  
Vol 390 ◽  
pp. 280-293
Author(s):  
Jiaxin Zhao ◽  
Hongwei Wang ◽  
Wenzheng Liu ◽  
Heming Zhang

2015 ◽  
Vol 83 ◽  
pp. 82-98 ◽  
Author(s):  
Matteo Zanetti ◽  
Antonio Cammi ◽  
Carlo Fiorina ◽  
Lelio Luzzi

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251297
Author(s):  
Pinaki Bhattacharya ◽  
Qiao Li ◽  
Damien Lacroix ◽  
Visakan Kadirkamanathan ◽  
Marco Viceconti

Throughout engineering there are problems where it is required to predict a quantity based on the measurement of another, but where the two quantities possess characteristic variations over vastly different ranges of time and space. Among the many challenges posed by such ‘multiscale’ problems, that of defining a ‘scale’ remains poorly addressed. This fundamental problem has led to much confusion in the field of biomedical engineering in particular. The present study proposes a definition of scale based on measurement limitations of existing instruments, available computational power, and on the ranges of time and space over which quantities of interest vary characteristically. The definition is used to construct a multiscale modelling methodology from start to finish, beginning with a description of the system (portion of reality of interest) and ending with an algorithmic orchestration of mathematical models at different scales within the system. The methodology is illustrated for a specific but well-researched problem. The concept of scale and the multiscale modelling approach introduced are shown to be easily adaptable to other closely related problems. Although out of the scope of this paper, we believe that the proposed methodology can be applied widely throughout engineering.


2016 ◽  
Author(s):  
Joon Yong An ◽  
Charles Claudianos

Abstract:The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major challenge. Recent advances in genetic screening and systems biology approaches have extended our knowledge of the genetic etiology of ASD. In this review, we discuss the paradigm shift from a single gene causation model to pathway perturbation model as a guide to better understand the pathophysiology of ASD. We discuss recent genetic findings obtained through next-generation sequencing (NGS) and examine various integrative analyses using systems biology and complex networks approaches that identify convergent patterns of genetic elements associated with ASD. This review provides a summary of the genetic findings of family-based genome screening studies.


Author(s):  
Alain Dequidt ◽  
Sébastien Garruchet ◽  
Benoit Latour ◽  
Nicolas Martzel ◽  
Ronald Blaak ◽  
...  

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