scholarly journals SUN-143 MATRIX METALLOPROTEINASE-10 (MMP-10) IS A KEY MOLECULE IN ALDOSTERONE-INDUCED GLOMERULAR INJURY IN SYSTEMIC GUANYLYL CYCLASE-A KNOCKOUT MICE

2019 ◽  
Vol 4 (7) ◽  
pp. S217
Author(s):  
H. Yokoi ◽  
K. Osaki ◽  
Y. Kato ◽  
N. Toda ◽  
A. Ishii ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Guanylyl Cyclase ◽  
Knockout Mice ◽  
Glomerular Injury

scholarly journals Enzymatic Relay Mechanism Stimulates Cyclic GMP Synthesis in Rod Photoresponse: Biochemical and Physiological Study in Guanylyl Cyclase Activating Protein 1 Knockout Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47637 ◽  
Author(s):  
Clint L. Makino ◽  
Xiao-Hong Wen ◽  
Elena V. Olshevskaya ◽  
Igor V. Peshenko ◽  
Andrey B. Savchenko ◽  
...  
Keyword(s):  
Cyclic Gmp ◽  
Guanylyl Cyclase ◽  
Knockout Mice ◽  
Physiological Study

scholarly journals Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury

2012 ◽  
Vol 23 (7) ◽  
pp. 1198-1209 ◽  
Author(s):  
Yoshihisa Ogawa ◽  
Masashi Mukoyama ◽  
Hideki Yokoi ◽  
Masato Kasahara ◽  
Kiyoshi Mori ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Guanylyl Cyclase ◽  
Natriuretic Peptide Receptor ◽  
Glomerular Injury ◽  
Peptide Receptor

Angiotensin II-Induced Hypertension Is Attenuated by Reduction of Sympathetic Output in NO-Sensitive Guanylyl Cyclase 1 Knockout Mice

2015 ◽  
Vol 356 (1) ◽  
pp. 191-199 ◽  
Author(s):  
K. Broekmans ◽  
J. Stegbauer ◽  
S. A. Potthoff ◽  
M. Russwurm ◽  
D. Koesling ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Guanylyl Cyclase ◽  
Knockout Mice ◽  
Induced Hypertension

scholarly journals Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

2011 ◽  
Vol 13 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Li-xia Yang ◽  
Zhi-hua Yang ◽  
Rui-wei Guo ◽  
Jin-shan Ye ◽  
Hong Liu
Keyword(s):  
Extracellular Matrix ◽  
Angiotensin Ii ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Ang Ii ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Apolipoprotein E Knockout Mice ◽  
Apoe Knockout Mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout mice were fed a high fat diet to establish an atherosclerosis model then intervention was made with Ang II and valsartan. EMMPRIN gene and its protein expression were measured by real-time PCR immunohistochemistry, and Western blot. Results: EMMPRIN gene and protein expression intervened with Ang II were significantly increased; valsartan could inhibit the effect of Ang II. Conclusion: Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R, and valsartan could inhibit the effect of Ang II.

Sign in / Sign up

Export Citation Format

Share Document