Knockout Mice of Matrix Metalloproteinase Genes

2003 ◽  
pp. 299-307
Author(s):  
Akiko Okada ◽  
Motoharu Seiki
Keyword(s):  
Matrix Metalloproteinase ◽  
Knockout Mice

scholarly journals Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

2011 ◽  
Vol 13 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Li-xia Yang ◽  
Zhi-hua Yang ◽  
Rui-wei Guo ◽  
Jin-shan Ye ◽  
Hong Liu
Keyword(s):  
Extracellular Matrix ◽  
Angiotensin Ii ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Ang Ii ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Apolipoprotein E Knockout Mice ◽  
Apoe Knockout Mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout mice were fed a high fat diet to establish an atherosclerosis model then intervention was made with Ang II and valsartan. EMMPRIN gene and its protein expression were measured by real-time PCR immunohistochemistry, and Western blot. Results: EMMPRIN gene and protein expression intervened with Ang II were significantly increased; valsartan could inhibit the effect of Ang II. Conclusion: Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R, and valsartan could inhibit the effect of Ang II.

scholarly journals Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice

2012 ◽  
Vol 28 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Yoshimi Takamiya ◽  
Kei Fukami ◽  
Sho-ichi Yamagishi ◽  
Yusuke Kaida ◽  
Yosuke Nakayama ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Matrix Metalloproteinase ◽  
Knockout Mice ◽  
Matrix Metalloproteinase 2

scholarly journals RECS1 is a Negative Regulator of Matrix Metalloproteinase-9 Production and Aged RECS1 Knockout Mice are Prone to Aortic Dilation

2006 ◽  
Vol 70 (5) ◽  
pp. 615-624 ◽  
Author(s):  
Hanjun Zhao ◽  
Akihiko Ito ◽  
Naohiko Sakai ◽  
Yuji Matsuzawa ◽  
Shizuya Yamashita ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Knockout Mice ◽  
Matrix Metalloproteinase 9 ◽  
Negative Regulator ◽  
Aortic Dilation ◽  
Metalloproteinase 9

scholarly journals ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis

2001 ◽  
Vol 107 (10) ◽  
pp. 1227-1234 ◽  
Author(s):  
Vincent Lemaître ◽  
Timothy K. O’Byrne ◽  
Alain C. Borczuk ◽  
Yasunori Okada ◽  
Alan R. Tall ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Knockout Mice ◽  
Matrix Metalloproteinase 1 ◽  
Apoe Knockout Mice
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