Fabrication of silk sericin/alginate microparticles by electrohydrodynamic spraying technique for the controlled release of silk sericin

2014 ◽  
Vol 72 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Peepattra Wantanasiri ◽  
Juthamas Ratanavaraporn ◽  
Rungnapha Yamdech ◽  
Pornanong Aramwit
Author(s):  
Theeraphol Phromsopha ◽  
Yodthong Baimark

This study aimed to develop the novel drug delivery carriers to control the release of silk sericin antioxidant. The chitosan/silk sericin blend microparticles were successfully prepared by the water-in-oil emulsification-diffusion method. Influence of silk sericin ratio on characteristics and in vitro silk sericin release behaviors of the blend microparticles was investigated. All the spherical-shaped blend microparticles had an average size of 41 – 48 m and could load the silk sericin in high loading efficiency (69 – 75%). The FTIR and thermogravimetric results indicated the blend microparticles with different silk sericin contents can be prepared by varying the silk sericin feed ratio. The blend microparticles exhibited sustained release profiles of the silk sericin. The in vitro silk sericin release content increased as the silk sericin ratio increased. Antioxidant activities of the blend microparticles assessed by FRAP assay were more than the neat chitosan microparticles and steadily increased with the silk sericin ratio. The results demonstrated that the chitosan/silk sericin blend microparticles prepared by the water-in-oil emulsification-diffusion method should be useful drug delivery carriers for the controlled release silk sericin antioxidant.


2009 ◽  
Vol 00 (00) ◽  
pp. 090805050810080-8 ◽  
Author(s):  
Handoko Adi ◽  
Paul Michael Young ◽  
Hak-Kim Chan ◽  
Rania Salama ◽  
Daniela Traini

Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website


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