Preparation of regenerated silk sericin/silk fibroin blend microparticles by emulsification–diffusion method for controlled release drug delivery

2016 ◽  
Vol 35 (4) ◽  
pp. 387-392 ◽  
Author(s):  
Yaowalak Srisuwan ◽  
Yodthong Baimark ◽  
Prasong Srihanam
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Silk Fibroin ◽  
Diffusion Method ◽  
Silk Sericin ◽  
Release Drug

Chitosan/Silk Sericin Blend Microparticles Prepared by Water-in-Oil Emulsification-Diffusion for Controlled Release of Silk Sericin Antioxidant

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Theeraphol Phromsopha ◽  
Yodthong Baimark
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Antioxidant Activities ◽  
Feed Ratio ◽  
Diffusion Method ◽  
Frap Assay ◽  
Silk Sericin ◽  
Average Size ◽  
Novel Drug

This study aimed to develop the novel drug delivery carriers to control the release of silk sericin antioxidant. The chitosan/silk sericin blend microparticles were successfully prepared by the water-in-oil emulsification-diffusion method. Influence of silk sericin ratio on characteristics and in vitro silk sericin release behaviors of the blend microparticles was investigated. All the spherical-shaped blend microparticles had an average size of 41 – 48 m and could load the silk sericin in high loading efficiency (69 – 75%). The FTIR and thermogravimetric results indicated the blend microparticles with different silk sericin contents can be prepared by varying the silk sericin feed ratio. The blend microparticles exhibited sustained release profiles of the silk sericin. The in vitro silk sericin release content increased as the silk sericin ratio increased. Antioxidant activities of the blend microparticles assessed by FRAP assay were more than the neat chitosan microparticles and steadily increased with the silk sericin ratio. The results demonstrated that the chitosan/silk sericin blend microparticles prepared by the water-in-oil emulsification-diffusion method should be useful drug delivery carriers for the controlled release silk sericin antioxidant.

Silk fibroin biomaterials for controlled release drug delivery

2011 ◽  
Vol 8 (6) ◽  
pp. 797-811 ◽  
Author(s):  
Eleanor M Pritchard ◽  
David L Kaplan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Silk Fibroin ◽  
Release Drug

scholarly journals Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Materials ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 281 ◽  
Author(s):  
Yong Xie ◽  
Xinxin Ma ◽  
Xujie Liu ◽  
Qingming Long ◽  
Yu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Drug ◽  
Release Drug ◽  
Anti Cancer ◽  
Carrier Free

scholarly journals PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

2017 ◽  
Vol 10 (3) ◽  
pp. 271 ◽  
Author(s):  
Sreeja C Nair ◽  
Karthika Ramesh ◽  
Krishnapriya M ◽  
Asha Paul
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Controlled Release ◽  
Sodium Alginate ◽  
Physical Parameters ◽  
Effective Management ◽  
Release Drug ◽  
Conventional Drug ◽  
Preparation And Evaluation ◽  
Evaluation Parameters

ABSTRACTObjective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres forthe purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into thenatural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within theacceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.

Polymer-Coated Gold Nanostructures for Controlled Release Drug Delivery

2020 ◽  
pp. 169-193
Author(s):  
JINGYI CHEN ◽  
TENGJIAO WANG ◽  
DANIEL MEEKER ◽  
MARK SMELTZER
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Gold Nanostructures ◽  
Release Drug
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