In this paper, comparative thermodynamic analysis of system-1 (multiple evaporators and compressors with individual expansion valves) and system-2 (multiple evaporators and compressors with multiple expansion valves) has been presented which is based on energy and exergy principles. The comparison of systems-1 and -2 using ecofriendly R410A, R290, R1234YF, R502, R404A, R152A and R134A refrigerants was done in terms of COP (energetic efficiency), exergetic efficiency and system defect. Numerical model has been developed for systems-1 and -2 for finding out irreversibility and it was observed that system-2 is better system in comparison with system-1 for selected refrigerants. It was also found that R152a shows better performances than other considered refrigerants for both systems.