Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration—A case study

2013 ◽  
Vol 106 (1-2) ◽  
pp. 230-236 ◽  
Author(s):  
Jacqueline A. French ◽  
Javier Cabrera ◽  
Birol Emir ◽  
Ed Whalen ◽  
Feihan Lu
Author(s):  
Srinivasa Rao Gadde ◽  
Naga Durgamamba A

This research reveals a group acceptance sampling plan (GASP) for lot resubmitting is designed for conditions wherein an item life is taken from the size biased Lomax distribution (SBLD). The plan parameters of the GASP are obtained by fulfilling the prefixed producer’s and consumer’s risks as per the test completion time and the number of testers. The projected plan needs a minimal sample size in comparison with the standard GASP. This proposed plan is justified with an example.


Author(s):  
Bernhard Spangl ◽  
Norbert Kaiblinger ◽  
Peter Ruckdeschel ◽  
Dieter Rasch

2013 ◽  
Vol 706-708 ◽  
pp. 2053-2056
Author(s):  
Kang Fu ◽  
Ying Xu ◽  
Jun Yang ◽  
Wei Zhang

In order to solve problem about how to test inherent availability of repairable system under minimum operating time and lognormal repair time, an inherent availability test procedure with fixed sample size is presented. The test procedure which is divided into alternate operating and repair process, should meet stated levels of producer’s risk and consumer’s risk. It is noticeable that minimal sample size and critical value calculation method research is considered as the key point of procedure design. At the end of this paper, course of a test procedure design and operation of inherent availability test and evaluation are described by example analysis.


Author(s):  
Д.А. Грачев ◽  
Е.А. Михайлов

Статья посвящена двухточечным моментам решений, возникающих в простых лагранжевых моделях для уравнения индукции в случае конечного корреляционного времени случайной среды. Рассматривается вопрос о связи коммутационных свойств соответствующих алгебраических операторов с минимальным объемом выборки независимых случайных реализаций, который необходим в численном эксперименте для моделирования двуточечного коррелятора решения. Показано, что, как и для одноточечных моментов, численное исследование двуточечного коррелятора в случае коммутирующих операторов (случайные числа) требует существенно меньших объемов выборки, чем в случае, когда они не коммутируют (случайные матрицы). This paper is devoted to the two-point moments of the solutions arising in simple Lagrange models for the induction equations in the case of finite correlation time of a random medium. We consider the question on the connection between the commutative properties of the corresponding algebraic operators and the minimal sample size of independent random realizations necessary in numerical experiments for modeling the two-point correlator of the solution. It is shown that, as for the one-point moments, the numerical study of the two-point correlator in the case of commutating operators (random numbers) requires a much smaller sample size than in the case when they do not commute (random matrices).


2011 ◽  
Vol 39 (3) ◽  
pp. 523-552 ◽  
Author(s):  
INGE MOLEMANS ◽  
RENATE VAN DEN BERG ◽  
LIEVE VAN SEVEREN ◽  
STEVEN GILLIS

ABSTRACTVarious measures for identifying the onset of babbling have been proposed in the literature, but a formal definition of the exact procedure and a thorough validation of the sample size required for reliably establishing babbling onset is lacking. In this paper the reliability of five commonly used measures is assessed using a large longitudinal corpus of spontaneous speech from forty infants (age 0 ; 6−2 ; 0). In a first experiment it is shown that establishing the onset of babbling with reasonable (95%) confidence is impossible when the measures are computed only once, and when the number of vocalizations are not equal for all children at all ages. In addition, each measure requires a different minimal sample size. In the second experiment a robust procedure is proposed and formally defined that permits the identification of the onset of babbling with 95% confidence. The bootstrapping procedure involves extensive resampling and requires relatively few data.


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