Proximal clavicular osteochondroma: A report of an unusual site

Extragastrointestinal stromal tumors (EGISTs) are rare tumors that arise outside the digestive tract. We report a case of an EGIST arising in the subcutaneous tissue of the abdominal wall, which at this site can often be misdiagnosed as dermatofibrosarcoma protuberans. The tumor was surgically resected from a 72-year-old male Chinese Han patient, and pathological examination revealed spindle-shaped tumor cells with eosinophilic cytoplasm and an oval nucleus. Immunohistochemically, the tumor cells showed strong cytoplasmic positivity for CD34, c-KIT (CD117), and DOG1. Tests for activating mutations of GISTs showed that the tumor cells carried an in-frame deletion (NP_000213.1:p.Lys550_Gln556del) in exon 11 of c-KIT (CD117). Thus, an EGIST should be considered in patients with abdominal subcutaneous tumors with an epithelioid, spindle-shaped, or mixed morphology. Immunohistochemistry of c-KIT (CD117) and DOG1 and genetic testing for activating mutations are recommended to aid in the differential diagnosis of subcutaneous tumors. In short, although EGISTs are rare in the abdominal subcutaneous tissue, pathologists must be aware of their possibility.

Download Full-text

Mycetoma – An unusual site

Surgery ◽

10.1067/msy.2000.102605 ◽

2000 ◽

Vol 127 (6) ◽

pp. 709-710 ◽

Cited By ~ 2

Author(s):

Naresh Soni ◽

Ashwini Gupta ◽

N.S. Shekhawat

Keyword(s):

Unusual Site

Download Full-text

Large Pulmonary Vein Varix Diagnosed by Transesophageal Echocardiography: An Unusual Site for Thrombus in Atrial Fibrillation

Journal of the American Society of Echocardiography ◽

10.1016/s0894-7317(98)70080-x ◽

1998 ◽

Vol 11 (2) ◽

pp. 213-215 ◽

Cited By ~ 5

Author(s):

Vivek J. Bhaktaram ◽

Sam Asirvatham ◽

Cherian Sebastian ◽

Krishnaswamy Chandrasekaran ◽

Chittur A. Sivaram

Keyword(s):

Atrial Fibrillation ◽

Transesophageal Echocardiography ◽

Pulmonary Vein ◽

Unusual Site

Download Full-text

A Carcinosarcoma/Sarcomatoid Carcinoma Arising in a Urinary Bladder Diverticulum

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-0853-acscai ◽

2002 ◽

Vol 126 (7) ◽

pp. 853-855 ◽

Cited By ~ 1

Author(s):

Atilla Omeroglu ◽

Gladell P. Paner ◽

Eva M. Wojcik ◽

Kalliopi Siziopikou

Keyword(s):

Urinary Bladder ◽

Sarcomatoid Carcinoma ◽

High Grade ◽

Bladder Diverticulum ◽

Unusual Site ◽

Muscular Layer ◽

Spindle Cells ◽

Aggressive Tumor ◽

Glandular Structures ◽

Pleomorphic Cells

Abstract We describe an invasive polypoid carcinosarcoma/sarcomatoid carcinoma arising within a urinary bladder diverticulum in a 65-year-old patient with synchronous, moderately differentiated prostatic adenocarcinoma. Histologically, the diverticular tumor exhibits an admixture of different morphologic components, including invasive high-grade urothelial carcinoma, malignant glandular structures in a cellular background of malignant spindle cells, and areas formed exclusively by spindle and pleomorphic cells. There was full-thickness involvement of the diverticulum with extension of the tumor into the perivesical fat and ipsilateral seminal vesicle. In view of the early invasive behavior of carcinosarcoma/sarcomatoid carcinoma combined with the paucity of the muscular layer in the diverticulum wall, a graver prognosis was expected for this aggressive tumor that occurred in this unusual site.

Download Full-text

An Unusual Site of Osteoid Osteoma in the Proximal Phalanx of a Finger

Journal of Hand Surgery (European Volume) ◽

10.1016/0266-7681_89_90100-9 ◽

1989 ◽

Vol 14 (3) ◽

pp. 341-344

Author(s):

S. C. CHEN ◽

H. CAPLAN

Keyword(s):

Osteoid Osteoma ◽

Proximal Phalanx ◽

Unusual Site

Download Full-text

False diagnosis of and needless therapy for presumed gestational trophoblastic disease in women with an unusual site of residual pregnancy

Journal of International Medical Research ◽

10.1177/0300060518807600 ◽

2018 ◽

Vol 47 (2) ◽

pp. 673-681 ◽

Cited By ~ 1

Author(s):

Tong Gao ◽

Mingming Sun ◽

Liangqing Yao ◽

Wei Jiang

Keyword(s):

Clinical Manifestations ◽

Diagnostic Value ◽

Gestational Trophoblastic Disease ◽

High Serum ◽

Resonance Imaging ◽

Unusual Site ◽

Pelvic Mri ◽

Trophoblastic Disease ◽

False Diagnosis ◽

Magnetic Resonance Imaging Mri

Objective This study aimed to determine the diagnostic value of magnetic resonance imaging (MRI), hysteroscopy, and laparoscopy to avoid unnecessary treatment when patients present with clinical manifestations that are close to those of gestational trophoblastic neoplasia (GTN). Methods Three patients who were falsely diagnosed with presumed GTN and received needless chemotherapy in our hospital from July 2011 to March 2012 were studied. We also reviewed data of patients with similar clinical features who were diagnosed as having residual pregnancy in recent years. Clinical manifestations were evaluated. Results All three patients had persistently high serum β-human chorionic gonadotrophin levels and a mass with abundant blood supply in the uterus after termination of pregnancy. The patients were diagnosed with GTN and underwent chemotherapy. They responded poorly to chemotherapy and underwent surgery. The pathological diagnosis in all patients was residual pregnancy. In recent years, no patients were misdiagnosed because pelvic MRI, hysteroscopy, or laparoscopy was used when residual pregnancy could not be excluded. Conclusion Gynecologists should diagnose carefully when patients present with clinical manifestations that are close to those of GTN to avoid unnecessary treatment. MRI, hysteroscopy, and laparoscopy could be important examinations for excluding residual pregnancy.

Download Full-text