Effects of Geiji-Bokryung-Hwan on common carotid artery elasticity and erythrocyte deformability in healthy male subjects – A pilot randomized controlled crossover study

2018 ◽  
Vol 18 ◽  
pp. 47-51
Author(s):  
Woo-Sang Jung ◽  
Seungwon Kwon ◽  
Seung-Yeon Cho ◽  
Seong-Uk Park ◽  
Sang-Kwan Moon ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Crossover Study ◽  
Common Carotid Artery ◽  
Erythrocyte Deformability ◽  
Healthy Male ◽  
Randomized Controlled ◽  
Male Subjects ◽  
Carotid Artery Elasticity

Variation of common carotid artery elasticity with intimal-medial thickness: The aric study

1997 ◽  
Vol 23 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Ward A. Riley ◽  
Gregory W. Evans ◽  
A. Richey Sharrett ◽  
Gregory L. Burke ◽  
Ralph W. Barnes
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Intimal Medial Thickness ◽  
Aric Study ◽  
Carotid Artery Elasticity

scholarly journals Structural, Functional, and Hemodynamic Changes of the Common Carotid Artery With Age in Male Subjects

1999 ◽  
Vol 19 (4) ◽  
pp. 1091-1097 ◽  
Author(s):  
Arno Schmidt-Trucksäss ◽  
Dominik Grathwohl ◽  
Andreas Schmid ◽  
Raffael Boragk ◽  
Christine Upmeier ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Hemodynamic Changes ◽  
The Common ◽  
Male Subjects

scholarly journals Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Patcharanee Tawasri ◽  
Chadarat Ampasavate ◽  
Somsak Tharatha ◽  
Natthakarn Chiranthanut ◽  
Supanimit Teekachunhatean
Keyword(s):  
Ascorbic Acid ◽  
Single Dose ◽  
Plasma Concentration ◽  
Crossover Study ◽  
Biologically Active ◽  
Pharmacokinetic Parameters ◽  
Healthy Male ◽  
Ganoderic Acid ◽  
To Receive ◽  
Male Subjects

The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched to receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points for 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry (LC-MS). The pharmacokinetic parameters analyzed were maximal plasma concentration (Cmax), time to reach peak concentration (Tmax), area under the plasma concentration-time curve (AUC), and half-life (t1/2). An oral coadministration of ascorbic acid with Ling Zhi preparation did not significantly alter the pharmacokinetic parameters of ganoderic acid A in healthy male subjects.

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