P.050 Hemodynamic response to methylphenidate in children with attention deficit hyperactivity disorder: first administration, titration phase and associations with clinical severity

Background: Clinical features of attention deficit hyperactivity disorder can be frequently observed in cases with bipolar disorders and associated with greater severity of bipolar disorders. Although designed as a screening tool for attention deficit hyperactivity disorder, the Wender Utah Rating Scale could, given its factorial structure, be useful in investigating the early history of impulsive, inattentive or mood-related symptoms among patients with bipolar disorders. Methods: We rated the Wender Utah Rating Scale in 276 adult bipolar disorder cases and 228 healthy controls and tested its factorial structure and any associations with bipolar disorder phenomenology. Results: We confirmed a three-factor structure for the Wender Utah Rating Scale (‘ impulsivity/temper’, ‘ inattentiveness’ and ‘ mood/self-esteem’). Cases and controls differed significantly on Wender Utah Rating Scale total score and sub-scale scores ( p-values < 10−5). About 23% of bipolar disorder cases versus 5% of controls were classified as ‘ WURS positive’ (odds ratio = 5.21 [2.73–9.95]). In bipolar disorders, higher Wender Utah Rating Scale score was associated with earlier age at onset, severity of suicidal behaviors and polysubstance misuse; multivariate analyses, controlling for age and gender, confirmed the associations with age at onset ( p = 0.001) and alcohol and substance misuse ( p = 0.001). Conclusion: Adults with bipolar disorders who reported higher levels of childhood symptoms on the Wender Utah Rating Scale presented a more severe expression of bipolar disorders in terms of age at onset and comorbidity. The Wender Utah Rating Scale could be employed to screen for attention deficit hyperactivity disorder but also for ‘ at-risk behaviors’ in adult bipolar disorder cases and possibly for prodromal signs of early onset in high-risk subjects.

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Reduced prefrontal hemodynamic response in adult attention‐deficit hyperactivity disorder as measured by near‐infrared spectroscopy

Psychiatry and Clinical Neurosciences ◽

10.1111/pcn.12643 ◽

2018 ◽

Vol 72 (6) ◽

pp. 380-390 ◽

Cited By ~ 1

Author(s):

Shotaro Ueda ◽

Toyosaku Ota ◽

Junzo Iida ◽

Kazuhiko Yamamuro ◽

Hiroki Yoshino ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Attention Deficit ◽

Near Infrared ◽

Hemodynamic Response ◽

Hyperactivity Disorder

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Hemodynamic response to facial expressions in children with attention-deficit/hyperactivity disorder (AD/HD)

The Proceedings of the Annual Convention of the Japanese Psychological Association ◽

10.4992/pacjpa.76.0_1evc02 ◽

2012 ◽

Vol 76 (0) ◽

pp. 1EVC02-1EVC02

Author(s):

Hiroko ICHIKAWA ◽

Emi NAKATO ◽

Keiichi SHIMAMURA ◽

Yuiko SAKUTA ◽

So KANAZAWA ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Facial Expressions ◽

Attention Deficit ◽

Hemodynamic Response ◽

Hyperactivity Disorder

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Insomnia Disorder in Adult Attention-Deficit/Hyperactivity Disorder Patients: Clinical, Comorbidity, and Treatment Correlates

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.663889 ◽

2021 ◽

Vol 12 ◽

Author(s):

Christian Fadeuilhe ◽

Constanza Daigre ◽

Vanesa Richarte ◽

Lara Grau-López ◽

Raul F. Palma-Álvarez ◽

...

Keyword(s):

Quality Of Life ◽

Attention Deficit Hyperactivity Disorder ◽

Attention Deficit ◽

Adult Adhd ◽

Rating Scales ◽

Clinical Severity ◽

Hyperactivity Disorder ◽

Insomnia Disorder ◽

Adhd Treatment

Introduction: Several investigations have been performed on insomnia symptoms in adult attention-deficit/hyperactivity disorder (ADHD). However, the relationship between insomnia disorder and adult ADHD has been neglected in research. The main objective of the current study is to analyze the differences between adult ADHD patients with and without insomnia disorder, in terms of ADHD clinical severity, medical and psychiatric comorbidity, psychopharmacological treatment, and quality of life.Material and Methods: Two hundred and fifty-two adult patients with ADHD (mean age 37.60 ± 13.22 years; ADHD presentations—combined: 56.7%, inattentive: 39.7%, hyperactive/impulsive: 3.6%) were evaluated with an exhaustive clinical and psychological evaluation protocol including semistructured interviews (for comorbidities and ADHD assessment) and symptom rating scales for ADHD. The diagnosis of ADHD and insomnia disorder was made according to DSM-5 criteria. Furthermore, the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Epworth Sleepiness Scale were administered.Results: Insomnia disorder was found in 44.4% of adult ADHD patients and was more common in combined presentation (64.3%) and in patients with more ADHD severity. Comorbidities (both medical and psychiatric), especially mood disorders (42%), anxiety disorder (26.8%), personality disorder (39.3%), and any substance use disorder (11.6%), were associated with a higher insomnia disorder prevalence. ADHD stimulant treatment was related to lower insomnia disorder compared to patients without medication, as well as ADHD stable treatment. Additionally, worse health-related quality of life was associated with insomnia disorder.Conclusion: Insomnia disorder is highly prevalent in adult ADHD and is related to higher ADHD severity and more psychiatric and medical comorbidities. Some stimulants and stable pharmacological ADHD treatment are associated with better outcomes of insomnia disorder.

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