A series of enzyme-controlled-release polymer-platinum-based drug conjugates for the treatment of gastric cancer

2017 ◽  
Vol 92 ◽  
pp. 105-116 ◽  
Author(s):  
Tianyi Shi ◽  
Lianshuai Gu ◽  
Yu Sun ◽  
Senlin Wang ◽  
Xiangyang Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Controlled Release ◽  
Drug Conjugates ◽  
Controlled Release Polymer

Controlled release of free doxorubicin from peptide–drug conjugates by drug loading

2014 ◽  
Vol 191 ◽  
pp. 123-130 ◽  
Author(s):  
Zhipeng Chen ◽  
Pengcheng Zhang ◽  
Andrew G. Cheetham ◽  
Jae Hyon Moon ◽  
James W. Moxley ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Peptide Drug ◽  
Drug Conjugates ◽  
Free Doxorubicin ◽  
Peptide Drug Conjugates

scholarly journals Prevention of Experimental Cerebral Vasospasm by Intracranial Delivery of a Nitric Oxide Donor From a Controlled-Release Polymer

Stroke ◽  
2002 ◽  
Vol 33 (11) ◽  
pp. 2681-2686 ◽  
Author(s):  
Patrik Gabikian ◽  
Richard E. Clatterbuck ◽  
Charles G. Eberhart ◽  
Betty M. Tyler ◽  
Travis S. Tierney ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Controlled Release ◽  
Cerebral Vasospasm ◽  
Nitric Oxide Donor ◽  
Controlled Release Polymer

Abstract 2901: Gastric cancer antibody fragment drug-conjugates (FDCs): From concept to clinical development

2020 ◽  
Author(s):  
Mahendra P. Deonarain ◽  
Gokhan Yahioglu ◽  
ioanna Stamati ◽  
Bryan Edwards ◽  
Soraya Diez-Posada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antibody Fragment ◽  
Clinical Development ◽  
Drug Conjugates

PLGA nanoparticle-based docetaxel/LY294002 drug delivery system enhances antitumor activities against gastric cancer

2019 ◽  
Vol 33 (10) ◽  
pp. 1394-1406 ◽  
Author(s):  
Juan Cai ◽  
Keyang Qian ◽  
Xueliang Zuo ◽  
Wuheng Yue ◽  
Yinzhu Bian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Mouse Model ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Poly Lactic Acid ◽  
Antitumor Effects

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites. The in vitro functional results showed that PLGA(TXT+LY294002) exhibited controlled-release and resulted in a markedly reduced proliferative capacity and an elevated apoptosis rate. An in vivo orthotopic GC mouse model and xenograft mouse model confirmed the anticancer superiority and tumor-targeting feature of PLGA(TXT+LY294002). Histological analysis indicated that PLGA(TXT+LY294002) was biocompatible and had no toxicity to major organs. Characterized by the combined slow release of TXT and LY294002, this novel PLGA-based TXT/LY294002 drug delivery system provides controlled release and tumor targeting and is safe, shedding light on the future of targeted therapy against GC.

Brain biocompatibility of a biodegradable controlled release polymer consisting of anhydride copolymer of fatty acid dimer and sebacic acid

1992 ◽  
Vol 19 (1-3) ◽  
pp. 325-329 ◽  
Author(s):  
Henry Brem ◽  
Abraham Domb ◽  
Doris Lenartz ◽  
Catalino Dureza ◽  
Alessandro Olivi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Controlled Release ◽  
Sebacic Acid ◽  
Controlled Release Polymer

Zero-Order Controlled-Release Polymer Matrices for Micro- and Macromolecules

1983 ◽  
Vol 72 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Dean S.T. Hsieh ◽  
William D. Rhine ◽  
Robert Langer
Keyword(s):  
Controlled Release ◽  
Zero Order ◽  
Polymer Matrices ◽  
Controlled Release Polymer

Biocompatibility of a Biodegradable, Controlled-Release Polymer in the Rabbit Brain

1989 ◽  
Vol 5 (2) ◽  
pp. 55-65 ◽  
Author(s):  
HENRY BREM ◽  
ABRAHAM KADER ◽  
JONATHAN I. EPSTEIN ◽  
RAFAEL J. TAMARGO ◽  
ABRAHAM DOMB ◽  
...  
Keyword(s):  
Controlled Release ◽  
Rabbit Brain ◽  
Controlled Release Polymer
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