scholarly journals Adults with persistent ADHD: Gender and psychiatric comorbidities – a population-based longitudinal study

2016 ◽  
Vol 33 (S1) ◽  
pp. S136-S137 ◽  
Author(s):  
K. Yoshimasu ◽  
W.J. Barbaresi ◽  
R.C. Colligan ◽  
R.G. Voigt ◽  
J.M. Killian ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Population Based ◽  
Psychiatric Interview ◽  
Psychiatric Comorbidities ◽  
Childhood Adhd ◽  
Comorbid Psychiatric Disorders ◽  
Increased Risk

ObjectiveTo evaluate in adults the associations between persistent ADHD and comorbid psychiatric disorders and gender differences, among subjects from a population-based birth cohort.MethodSubjects were recruited from a birth cohort of all children born during 1976–1982 who remained in Rochester, MN after five years of age. Participating subjects with research-identified childhood ADHD (n = 232; mean age 27.0 years; 72% men) and non-ADHD controls (n = 335; mean age 28.6 years; 63% men) were administered a structured psychiatric interview (MINI-International Neuropsychiatric Interview) to assess current ADHD status and comorbid psychiatric disorders.ResultsAmong the 232 with research-identified childhood ADHD, 68 (49 men and 19 women) had persistent adult ADHD. Compared to subjects without childhood ADHD, adults with persistent ADHD were significantly more likely to have any (81% vs. 35%, P < 0.001) as well as each of the specific psychiatric comorbidities. The associations retained significance when stratified by gender and there were no significant gender by ADHD interactions on psychiatric disorders except for dysthymia with which ADHD was more strongly associated in women than men. Among subjects with persistent ADHD, externalizing psychiatric disorders were more common in men (73%) and internalizing disorders were more common in women (53%).ConclusionPersistent ADHD is associated with an increased risk of comorbid psychiatric disorders in both adult men and women. Clinicians treating adults with persistent ADHD need to be aware of comorbid psychiatric disorders, especially externalizing disorders for men and internalizing disorders for women.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Suicidality and psychiatric comorbidities among adults with childhood identified ADHD: Gender differences – a population-based longitudinal study

2016 ◽  
Vol 33 (S1) ◽  
pp. S77-S77
Author(s):  
K. Yoshimasu ◽  
W.J. Barbaresi ◽  
R.C. Colligan ◽  
R.G. Voigt ◽  
J.M. Killian ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Interaction Effect ◽  
Odds Ratio ◽  
Population Based ◽  
Suicidal Risk ◽  
Psychiatric Interview ◽  
Psychiatric Comorbidities ◽  
Childhood Adhd ◽  
Comorbid Psychiatric Disorders ◽  
Competing Interest

ObjectiveTo evaluate the effect of comorbid psychiatric disorders (PD) on the association between childhood ADHD and suicidality and the effect of gender on the association between PDs and suicidality among adults with childhood ADHD.MethodSubjects were recruited from a birth cohort of all children born 1976–1982 remaining in Rochester, MN after five years of age. Participating subjects with research-identified childhood ADHD (n = 232; mean age 27.0 years; 72% men) and non-ADHD controls (n = 335; mean age 28.6 years; 63% men) were administered a structured psychiatric interview (MINI International Neuropsychiatric Interview) to assess suicidality and psychiatric comorbidities.ResultsCompared to controls, ADHD cases were significantly more likely to meet criteria for suicidality [odds ratio (OR) = 2.7, 95% CI 1.7–4.5]. Although this association was not moderated by the presence of PDs (P = 0.63 for interaction effect), the association between ADHD and suicidality was partially mediated by the presence of PDs [OR decreased from 2.7 to 2.1 (95% CI 1.2–3.5)]. Among adults with childhood ADHD, there was no significant moderating effect of gender on the association between suicidality and PD (P = 0.26 for interaction effect). However, the odds of suicidality was 6.1 (95% CI, 2.3–15.9) times higher among males with both externalizing and internalizing PDs compared to males with no disorders; among females the corresponding odds ratio was 3.4 (95% CI, 0.7–16.6).ConclusionChildhood ADHD is significantly associated with adult suicidal risk. Among those with ADHD, associations between suicidality and comorbid psychiatric disorders are more apparent in men among those with comorbid externalizing and internalizing disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Adults With Persistent ADHD: Gender and Psychiatric Comorbidities—A Population-Based Longitudinal Study

2016 ◽  
Vol 22 (6) ◽  
pp. 535-546 ◽  
Author(s):  
Kouichi Yoshimasu ◽  
William J. Barbaresi ◽  
Robert C. Colligan ◽  
Robert G. Voigt ◽  
Jill M. Killian ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Adult Adhd ◽  
Structured Interview ◽  
Population Based ◽  
Psychiatric Comorbidities ◽  
Men And Women ◽  
Childhood Adhd ◽  
Comorbid Psychiatric Disorders ◽  
Adult Men ◽  
Increased Risk

Objective: The aim of the study was to evaluate associations between ADHD and comorbid psychiatric disorders among adults from a population-based birth cohort. Method: Participants were recruited from all children born between 1976 and 1982 remaining in Rochester, Minnesota, after age 5. Participants with childhood ADHD ( n = 232; M age = 27.0 years; 72% men) and non-ADHD controls ( n = 335; M age = 28.6 years; 63% men) completed a structured interview (M.I.N.I. International Neuropsychiatric Interview) assessing current ADHD status and comorbid psychiatric disorders. Results: Among 232 with childhood ADHD, 68 (49 men, 19 women) had persistent adult ADHD. Compared with non-ADHD controls and non-persistent ADHD participants, adults with persistent ADHD were significantly more likely to have any or each of 12 psychiatric comorbidities. The associations retained significant or marginally significant when stratified by gender. Externalizing psychiatric disorders were more common in men (74%) and internalizing disorders in women (58%). Conclusion: Persistent ADHD is associated with an increased risk of comorbid psychiatric disorders in adult men and women.

P01-306-Adhd, gender, and psychiatric comorbidity in a populaiton-based birth cohort

2011 ◽  
Vol 26 (S2) ◽  
pp. 308-308
Author(s):  
K. Yoshimasu ◽  
W.J. Barbaresi ◽  
R.C. Colligan ◽  
J.M. Killian ◽  
R.G. Voigt ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Cox Model ◽  
Population Based ◽  
Psychiatric Comorbidities ◽  
Children With Adhd ◽  
Comorbid Psychiatric Disorders ◽  
Oppositional Defiant ◽  
Increased Risk ◽  
Incident Cases

IntroductionADHD is frequently associated with comorbid psychiatric disorders. However, epidemiologic studies in the general population are rare.ObjectiveTo evaluate associations between ADHD and comorbid psychiatric disorders using research-identified incident ADHD cases and population-based controls.MethodSubjects included a birth cohort of all children born 1976-1982 remaining in Rochester, MN after age five (n = 5718). Among them we identified 379 ADHD incident cases and 758 age-sex matched non-ADHD controls, passively followed to age 19. Through a systematic, multistaged process, utilizing detailed, routinely collected data, all psychiatric diagnoses confirmed by medical professionals were identified (n = 314 ADHD cases, n = 712 controls with research authorization). For each psychiatric disorder, cumulative incidence rates for subjects with and without ADHD were calculated; corresponding hazard ratios (HR) adjusted for sex, mothers age/education, were estimated using a Cox model. Associations between ADHD status and Internalizing-Externalizing dimensions were estimated using odds ratios (OR).ResultsADHD was associated with significantly increased risk for adjustment disorders (HR = 3.82), conduct disorder/oppositional defiant disorder (HR = 9.45), mood disorders (HR = 3.57), anxiety disorders (HR = 2.95), tic disorders (HR = 6.41), eating disorders (HR = 5.52), personality disorders (HR = 5.49), and substance-related disorders (HR = 4.04). When psychiatric comorbidities were classified on the Internalizing-Externalizing dimension, ADHD was strongly associated with coexisting internalizing/externalizing (OR = 10.6, vs none), and externalizing-only (OR = 10.0), disorders. No significant gender x ADHD interactions were observed.ConclusionThis population-based study confirms that children with ADHD are at significant risk for co-morbid psychiatric disorders. Besides treating the ADHD, clinicians should assess and monitor potential psychiatric comorbidities in children with ADHD.

scholarly journals The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study

Genes ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 626
Author(s):  
Luciana Tovo-Rodrigues ◽  
Gabriela Quinte ◽  
Clarice Brum ◽  
Gabriele Ghisleni ◽  
Clarissa Bastos ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Well Being ◽  
Externalizing Disorders ◽  
Population Based ◽  
Current Data ◽  
Birth Cohort Study ◽  
Structured Interviews ◽  
Protein Coding

Background: It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. Methods: Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health. Results: We observed an association between rs4916723 (MIR9-2) and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130–0.944; p = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698–0.987; p = 0.035). rs4938723 (MIR34B/C) was not associated with any evaluated outcome. Conclusion: The study suggests that MIR9-2 may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems.

scholarly journals Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study

2012 ◽  
Vol 53 (10) ◽  
pp. 1036-1043 ◽  
Author(s):  
Kouichi Yoshimasu ◽  
William J. Barbaresi ◽  
Robert C. Colligan ◽  
Robert G. Voigt ◽  
Jill M. Killian ◽  
...  
Keyword(s):  
Cohort Study ◽  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Population Based ◽  
Birth Cohort Study ◽  
Childhood Adhd

Recalled Experiences of Bullying and Victimization in a Longitudinal, Population-Based Birth Cohort: The Influence of ADHD and Co-Occurring Psychiatric Disorder

2020 ◽  
pp. 108705472096998
Author(s):  
Jason M. Fogler ◽  
Amy L. Weaver ◽  
Slavica Katusic ◽  
Robert G. Voigt ◽  
William J. Barbaresi
Keyword(s):  
Psychiatric Disorders ◽  
Birth Cohort ◽  
Peer Interactions ◽  
Multinomial Logistic Regression ◽  
Secondary Data ◽  
Population Based ◽  
Future Research ◽  
Childhood Adhd ◽  
Causal Pathways ◽  
Bullying Experiences

Objective: To describe bullying experiences throughout childhood of people with and without childhood ADHD and co-occurring learning and psychiatric disorders from a population-based birth cohort. Methods: In a secondary data analysis of 199 childhood ADHD cases and 287 non-ADHD referents ( N = 486), reported experiences of peer interactions during elementary, middle, or high school were classified as “bully,” “victim,” “neither,” or “both.” Associations were assessed with multinomial logistic regression. Results: Adjusted for male sex, the odds of classification as victim-only, victim/bully, or bully- only (vs. neither) were 3.70 (2.36–5.81), 17.71, and 8.17 times higher for childhood ADHD cases compared to non-ADHD referents. Victim-bullies (62.5%) and bullies (64.3%) had both childhood ADHD and other psychiatric disorders versus 38.4% of victims-only and 17.3% of those classified as “neither.” Conclusion: The list of serious lifetime consequences of having ADHD also includes bullying. We offer future research directions for determining potential causal pathways.

Psychiatric Comorbidities Modify the Association Between Childhood ADHD and Risk for Suicidality: A Population-Based Longitudinal Study

2017 ◽  
Vol 23 (8) ◽  
pp. 777-786 ◽  
Author(s):  
Kouichi Yoshimasu ◽  
William J. Barbaresi ◽  
Robert C. Colligan ◽  
Robert G. Voigt ◽  
Jill M. Killian ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Population Based ◽  
Generalized Anxiety ◽  
Suicidal Risk ◽  
Psychiatric Interview ◽  
Psychiatric Comorbidities ◽  
Childhood Adhd ◽  
Synergistic Interactions ◽  
Substance Related Disorders ◽  
Hypomanic Episode

Objective: The objective of this study was to evaluate the effect of psychiatric comorbidities on the association between childhood ADHD and suicidality among adults. Method: Subjects were recruited from a population-based birth cohort. Participating adult subjects with childhood ADHD and non-ADHD controls were administered a structured psychiatric interview to assess suicidality and psychiatric comorbidities. Associations were assessed using logistic regression. Results: Compared with controls, ADHD cases were significantly more likely to meet criteria for suicidality. Subjects with childhood ADHD who met criteria for generalized anxiety disorder had a higher than expected risk of suicidality with an observed odds ratio of 10.94 (95% confidence interval [4.97, 24.08]) compared with an expected odds ratio of 4.86, consistent with a synergistic interaction effect. Significant synergistic interactions were also observed for hypomanic episode and substance-related disorders. Conclusion: Childhood ADHD is significantly associated with adult suicidal risk. Comorbidity between ADHD and some psychiatric disorders is associated with a higher suicidal risk than expected.

scholarly journals Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis

2018 ◽  
Vol 212 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Antti Mustonen ◽  
Solja Niemelä ◽  
Tanja Nordström ◽  
Graham K. Murray ◽  
Pirjo Mäki ◽  
...  
Keyword(s):  
Substance Use ◽  
General Population ◽  
Birth Cohort ◽  
Psychotic Disorders ◽  
Temporal Order ◽  
Population Based ◽  
Cannabis Use ◽  
Prodromal Symptoms ◽  
Increased Risk ◽  
Icd 10

BackgroundThe association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.AimsTo examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.MethodThe sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15–16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.ResultsThe risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0–13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1–8.0).ConclusionsAdolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.Declaration of interestNone.

Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study

2018 ◽  
Vol 49 (14) ◽  
pp. 2397-2404 ◽  
Author(s):  
Mu-Hong Chen ◽  
Ju-Wei Hsu ◽  
Kei-Lin Huang ◽  
Tung-Ping Su ◽  
Cheng-Ta Li ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Psychiatric Disorders ◽  
Population Based ◽  
Autism Spectrum ◽  
The Public ◽  
First Degree Relatives ◽  
Relative Risks ◽  
Dependent Relationship ◽  
Increased Risk ◽  
Bipolar Patients

AbstractBackgroundBipolar disorder is a highly heritable mental illness that transmits intergeneratively. Previous studies supported that first-degree relatives (FDRs), such as parents, offspring, and siblings, of patients with bipolar disorder, had a higher risk of bipolar disorder. However, whether FDRs of bipolar patients have an increased risk of schizophrenia, major depressive disorder (MDD), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) remains unclear.MethodsAmong the entire population in Taiwan, 87 639 patients with bipolar disorder and 188 290 FDRs of patients with bipolar disorder were identified in our study. The relative risks (RRs) of major psychiatric disorders were assessed among FDRs of patients with bipolar disorder.ResultsFDRs of patients with bipolar disorder were more likely to have a higher risk of major psychiatric disorders, including bipolar disorder (RR 6.12, 95% confidence interval (CI) 5.95–6.30), MDD (RR 2.89, 95% CI 2.82–2.96), schizophrenia (RR 2.64, 95% CI 2.55–2.73), ADHD (RR 2.21, 95% CI 2.13–2.30), and ASD (RR 2.10, 95% CI 1.92–2.29), than the total population did. These increased risks for major psychiatric disorders were consistent across different familial kinships, such as parents, offspring, siblings, and twins. A dose-dependent relationship was also found between risk of each major psychiatric disorder and numbers of bipolar patients.ConclusionsOur study was the first study to support the familial coaggregation of bipolar disorder with other major psychiatric disorders, including schizophrenia, MDD, ADHD, and ASD, in a Taiwanese (non-Caucasian) population. Given the elevated risks of major psychiatric disorders, the public health government should pay more attention to the mental health of FDRs of patients with bipolar disorder.

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