Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice

2005 ◽  
Vol 40 (1-2) ◽  
pp. 27-35 ◽  
Author(s):  
Danila Paula Argentino ◽  
Fernando Pablo Dominici ◽  
Marina Cecilia Muñoz ◽  
Khalid Al-Regaiey ◽  
Andrzej Bartke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Glucose Homeostasis ◽  
Insulin Signaling ◽  
Signaling System ◽  
Ames Dwarf

scholarly journals Effects of Long-Term Caloric Restriction on Early Steps of the Insulin-Signaling System in Mouse Skeletal Muscle

2005 ◽  
Vol 60 (1) ◽  
pp. 28-34 ◽  
Author(s):  
D. P. Argentino ◽  
F. P. Dominici ◽  
K. Al-Regaiey ◽  
M. S. Bonkowski ◽  
A. Bartke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Insulin Signaling ◽  
Signaling System ◽  
Mouse Skeletal Muscle

Long‐term caloric restriction abrogates the age‐related decline in skeletal muscle aerobic function

2005 ◽  
Vol 19 (10) ◽  
pp. 1320-1322 ◽  
Author(s):  
Russell T. Hepple ◽  
David J. Baker ◽  
Jan J. Kaczor ◽  
Daniel J. Krause
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Age Related ◽  
Aerobic Function

scholarly journals Effect of long‐term caloric restriction on mitochondrial function in skeletal muscle and non‐exercise activity in aged rats

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jill M Schimke ◽  
Stephane Walrand ◽  
Katherine A Klaus ◽  
Dawn Morse ◽  
Kevin R Short ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Mitochondrial Function ◽  
Aged Rats ◽  
Exercise Activity

Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice

1999 ◽  
Vol 277 (3) ◽  
pp. E447-E454 ◽  
Author(s):  
Fernando P. Dominici ◽  
Debora Cifone ◽  
Andrzej Bartke ◽  
Daniel Turyn
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Transgenic Mice ◽  
Tyrosine Phosphorylation ◽  
Insulin Signaling ◽  
Molecular Mechanisms ◽  
Kinase Activity ◽  
Signaling System ◽  
Phosphorylation State ◽  
Gh Excess

Growth hormone (GH) excess is associated with insulin resistance, but the molecular mechanisms of this association are poorly understood. In the current work, we have examined the consequences of exposure to high GH levels on the early steps of the insulin-signaling system in the muscle of bovine (b) GH-transgenic mice. The protein content and the tyrosine phosphorylation state of the insulin receptor (IR), the IR substrate-1 (IRS-1), the association between IRS-1 and the p85 subunit of phosphatidylinositol (PI) 3-kinase, and the phosphotyrosine-derived PI 3-kinase activity in this tissue were studied. We found that in skeletal muscle of bGH-transgenic mice, exposure to high circulating GH levels results in 1) reduced IR abundance, 2) reduced IR tyrosine phosphorylation, 3) reduced efficiency of IRS-1 tyrosine phosphorylation, and 4) defective activation of PI 3-kinase by insulin. These alterations may be related to the insulin resistance exhibited by these animals.

Caloric Restriction Modulates Early Events in Insulin Signaling in Liver and Skeletal Muscle of Rat

2004 ◽  
Vol 1019 (1) ◽  
pp. 448-452 ◽  
Author(s):  
MIN ZHU ◽  
RAFAEL CABO ◽  
MARK A. LANE ◽  
DONALD K. INGRAM
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Insulin Signaling

scholarly journals Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach

AGE ◽  
2011 ◽  
Vol 34 (2) ◽  
pp. 371-387 ◽  
Author(s):  
Gilbert Zeanandin ◽  
Michèle Balage ◽  
Stéphane M. Schneider ◽  
Joëlle Dupont ◽  
Xavier Hébuterne ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Differential Effect ◽  
Insulin Signaling Pathway ◽  
Leucine Supplementation ◽  
Old Rats

Effect of Long-Term Exercise on Gene Expression of Insulin Signaling Pathway Intermediates in Skeletal Muscle

1999 ◽  
Vol 254 (3) ◽  
pp. 720-727 ◽  
Author(s):  
Young-Bum Kim ◽  
Takatoshi Inoue ◽  
Rieko Nakajima ◽  
Yoko Shirai-Morishita ◽  
Kumpei Tokuyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Signaling Pathway

Differential insulin signaling regulation in skeletal muscle and adipose tissue from old rats fed a long-term leucine excess

2013 ◽  
Vol 23 ◽  
pp. S52
Author(s):  
Gilbert Zeanandin ◽  
Michèle Balage ◽  
Claire Sornet ◽  
Joëlle Dupont ◽  
Stéphane M. Schneider ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Insulin Signaling ◽  
Signaling Regulation ◽  
Old Rats
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