Adaptation of rat soleus muscle spindles after 21 days of hindlimb unloading

2006 ◽  
Vol 200 (1) ◽  
pp. 191-199 ◽  
Author(s):  
C. Rosant ◽  
M.D. Nagel ◽  
C. Pérot
Keyword(s):  
Soleus Muscle ◽  
Muscle Spindles ◽  
Hindlimb Unloading ◽  
Rat Soleus Muscle

scholarly journals Expression of Myosin Heavy Chain Isoforms Along Intrafusal Fibers of Rat Soleus Muscle Spindles After 14 Days of Hindlimb Unloading

2002 ◽  
Vol 50 (11) ◽  
pp. 1543-1553 ◽  
Author(s):  
L. De-Doncker ◽  
F. Picquet ◽  
G. Butler Browne ◽  
M. Falempin
Keyword(s):  
Soleus Muscle ◽  
Muscle Spindles ◽  
Myosin Heavy Chain Isoforms ◽  
Hindlimb Unloading ◽  
Cross Sectional ◽  
Intrafusal Fibers ◽  
Significant Difference ◽  
Slow Type ◽  
Rat Soleus Muscle

Morphological, contractile, histochemical, and electrophoretical characteristics of slow postural muscles are altered after hindlimb unloading (HU). However, very few data on intrafusal fibers (IFs) are available. Our aim was to determine the effects of 14 days of hindlimb unloading on the morphological and immunohistochemical characteristics of IF in rat soleus muscle. Thirty-three control and 32 unloaded spindles were analyzed. The number and distribution of muscle spindles did not appear to be affected after unloading. There was no significant difference in number, cross-sectional area, and histochemical properties of IF between the two groups. However, after unloading, a significant decrease in slow type 1 MHC isoform and a slight increase in slow-tonic MHC expression were observed in the B and C regions of the bag1 fibers. The α-cardiac MHC expression was significantly decreased along the entire length of the bag2 fibers and in the B and C regions of the bag1 fibers. In 12 muscle spindles, the chain fibers expressed the slow type 1 and α-cardiac MHC isoforms over a short distance of the A region, although these isoforms are not normally expressed. The most striking finding of the study was the relative resistance of muscle spindles to perturbation induced by HU.

scholarly journals Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle

2018 ◽  
Vol 69 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Toshinori Yoshihara ◽  
Toshiharu Natsume ◽  
Takamasa Tsuzuki ◽  
Shuo-wen Chang ◽  
Ryo Kakigi ◽  
...  
Keyword(s):  
Sex Differences ◽  
Soleus Muscle ◽  
Hindlimb Unloading ◽  
Forkhead Box ◽  
Rat Soleus Muscle ◽  
Forkhead Box O3a

scholarly journals Effect of L-Arginine on Titin Expression in Rat Soleus Muscle After Hindlimb Unloading

2019 ◽  
Vol 10 ◽  
Author(s):  
Anna Ulanova ◽  
Yuliya Gritsyna ◽  
Nikolai Salmov ◽  
Yuliya Lomonosova ◽  
Svetlana Belova ◽  
...  
Keyword(s):  
Soleus Muscle ◽  
Hindlimb Unloading ◽  
Rat Soleus Muscle

Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading

2010 ◽  
Vol 110 (6) ◽  
pp. 1215-1224 ◽  
Author(s):  
Davide Basco ◽  
Grazia Paola Nicchia ◽  
Jean-François Desaphy ◽  
Diana Conte Camerino ◽  
Antonio Frigeri ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Soleus Muscle ◽  
Hindlimb Unloading ◽  
Two Dimensional ◽  
Sds Page ◽  
Rat Soleus Muscle ◽  
Protein Alterations ◽  
Blue Native

Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle

2002 ◽  
Vol 282 (5) ◽  
pp. C1025-C1030 ◽  
Author(s):  
Laurence Stevens ◽  
Bruno Bastide ◽  
Philippe Kischel ◽  
Dirk Pette ◽  
Yvonne Mounier
Keyword(s):  
Soleus Muscle ◽  
Troponin I ◽  
Troponin T ◽  
Hindlimb Unloading ◽  
Heavy Chains ◽  
Mechanical Unloading ◽  
Fast Myosin ◽  
Rat Soleus Muscle ◽  
Subunit Isoforms ◽  
Time Courses

This study focuses on the effects of mechanical unloading of rat soleus muscle on the isoform patterns of the three troponin (Tn) subunits: troponin T (TnT), troponin I (TnI), and troponin C (TnC). Mechanical unloading was achieved by hindlimb unloading (HU) for time periods of 7, 15, and 28 days. Relative concentrations of slow and fast TnT, TnI, and TnC isoforms were assessed by electrophoretic and immunoblot analyses. HU induced profound slow-to-fast isoform transitions of all Tn subunits, although to different extents and with different time courses. The effectiveness of the isoform transitions was higher for TnT than for TnI and TnC. Indeed, TnI and TnC encompassed minor partial exchanges of slow isoforms with their fast counterparts, whereas the expression pattern of fast TnT isoforms (TnTf) was largely increased after HU. Moreover, slow and fast isoforms of the different Tn were not affected in the same manner by HU. This suggests that the slow and fast counterparts of the Tn subunit isoforms are regulated independently in response to HU. The changes in TnTf composition occurred in parallel with previously demonstrated transitions within the pattern of the fast myosin heavy chains in the same muscles.

Preventive effect of nucleoprotein on hindlimb unloading-induced capillary regression in rat soleus muscle

2013 ◽  
Vol 89 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Y Kanazawa ◽  
K Maekawa ◽  
Y Okumura ◽  
N Fujita ◽  
H Fujino
Keyword(s):  
Soleus Muscle ◽  
Hindlimb Unloading ◽  
Preventive Effect ◽  
Rat Soleus Muscle
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