Stroke-induced opposite and age-dependent changes of vessel-associated markers in co-morbid transgenic mice with Alzheimer-like alterations

2013 ◽  
Vol 250 ◽  
pp. 270-281 ◽  
Author(s):  
Cheryl A. Hawkes ◽  
Dominik Michalski ◽  
Rebecca Anders ◽  
Sabine Nissel ◽  
Jens Grosche ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Age Dependent

scholarly journals E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

2011 ◽  
Vol 286 (40) ◽  
pp. 35104-35118 ◽  
Author(s):  
Kristel L. Emmer ◽  
Elisa A. Waxman ◽  
Jason P. Covy ◽  
Benoit I. Giasson
Keyword(s):  
Transgenic Mice ◽  
Motor Impairment ◽  
Tau Pathology ◽  
Age Dependent

Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

2007 ◽  
Vol 28 (9) ◽  
pp. 1421-1435 ◽  
Author(s):  
Christian Freichel ◽  
Manuela Neumann ◽  
Theresa Ballard ◽  
Veronika Müller ◽  
Marie Woolley ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cognitive Decline ◽  
Age Dependent

scholarly journals Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

2018 ◽  
Vol 115 (7) ◽  
pp. 1635-1640 ◽  
Author(s):  
Yulan Xiong ◽  
Stewart Neifert ◽  
Senthilkumar S. Karuppagounder ◽  
Qinfang Liu ◽  
Jeannette N. Stankowski ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Molecular Mechanisms ◽  
Model Development ◽  
Behavioral Deficits ◽  
Lrrk2 G2019s ◽  
Age Dependent ◽  
Dependent Cell ◽  
A Cell ◽  
Mutant Lrrk2 ◽  
Familial Parkinson’S Disease

Mutations in LRRK2 are known to be the most common genetic cause of sporadic and familial Parkinson’s disease (PD). Multiple lines of LRRK2 transgenic or knockin mice have been developed, yet none exhibit substantial dopamine (DA)-neuron degeneration. Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice and show that LRRK2 GS expression leads to an age- and kinase-dependent cell-autonomous neurodegeneration of DA and norepinephrine (NE) neurons. Accompanying the loss of DA neurons are DA-dependent behavioral deficits and α-synuclein pathology that are also LRRK2 GS kinase-dependent. Transmission EM reveals that that there is an LRRK2 GS kinase-dependent significant reduction in synaptic vesicle number and a greater abundance of clathrin-coated vesicles in DA neurons. These transgenic mice indicate that LRRK2-induced DA and NE neurodegeneration is kinase-dependent and can occur in a cell-autonomous manner. Moreover, these mice provide a substantial advance in animal model development for LRRK2-associated PD and an important platform to investigate molecular mechanisms for how DA neurons degenerate as a result of expression of mutant LRRK2.

scholarly journals Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

2001 ◽  
Vol 21 (20) ◽  
pp. 8198-8209 ◽  
Author(s):  
Katrin I. Andreasson ◽  
Alena Savonenko ◽  
Sveta Vidensky ◽  
Joseph J. Goellner ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cognitive Deficits ◽  
Neuronal Apoptosis ◽  
Cyclooxygenase 2 ◽  
Age Dependent
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