scholarly journals Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia

2017 ◽  
Vol 295 ◽  
pp. 162-175 ◽  
Author(s):  
Mariangela Scarduzio ◽  
Chelsea N. Zimmerman ◽  
Karen L. Jaunarajs ◽  
Qin Wang ◽  
David G. Standaert ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Dyt1 Dystonia ◽  
Receptor Modulation ◽  
Cholinergic Tone ◽  
Cholinergic Interneuron

No evidence for dependence of early cortical auditory processing on dopamine D2-receptor modulation: a whole-head magnetoencephalographic study

2001 ◽  
Vol 107 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Seppo Kähkönen ◽  
Jyrki Ahveninen ◽  
Eero Pekkonen ◽  
Seppo Kaakkola ◽  
Juha Huttunen ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Receptor Modulation ◽  
Cortical Auditory Processing

scholarly journals Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24261 ◽  
Author(s):  
Giuseppe Sciamanna ◽  
Annalisa Tassone ◽  
Giuseppina Martella ◽  
Georgia Mandolesi ◽  
Francesca Puglisi ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Developmental Profile ◽  
Cholinergic Interneurons ◽  
Dopamine D2 ◽  
Dyt1 Dystonia ◽  
Receptor Response

Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats

2005 ◽  
Vol 288 (5) ◽  
pp. L910-L916 ◽  
Author(s):  
J. L. Carroll ◽  
K. M. Boyle ◽  
M. J. Wasicko ◽  
L. M. Sterni
Keyword(s):  
Intracellular Calcium ◽  
Time Course ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Body Type ◽  
Similar Time ◽  
Dopamine D2 ◽  
Receptor Modulation ◽  
Dopaminergic Modulation

Carotid chemoreceptor type 1 cells release dopamine, which inhibits carotid chemoreceptor activity via dopamine D2 autoreceptors on type 1 cells. Postnatal changes in dopaminergic modulation may be involved in postnatal chemoreceptor development. The present study explores dopaminergic modulation of the intracellular calcium ([Ca2+]i) response to hypoxia in type 1 cells from 1, 3, and 11- to 16-day-old rats. Using fura-2, we studied the effects of quinpirole, a D2 receptor agonist, on type 1 cell [Ca2+]i response to 90-s hypoxia challenges (Po2 ∼1–2 mmHg). Cells were sequentially exposed to the following challenges: 1) hypoxia control, 2) hypoxia plus quinpirole, and 3) hypoxia plus quinpirole plus sulpiride (D2 receptor antagonist). In the 11- to 16-day-old group, type 1 cell [Ca2+]i increased ∼3 to 4-fold over resting [Ca2+]i in response to hypoxia. Quinpirole (10 μM) significantly blunted the peak [Ca2+]i response to hypoxia. Repeat challenge with hypoxia plus 10 μM quinpirole in the presence of 10 μM sulpiride partially restored the hypoxia [Ca2+]i response. In sharp contrast to the older aged group, 10 μM quinpirole had minimal effect on hypoxia response of type 1 cells from 1-day-olds and a small but significant effect at 3 days of age. We conclude that stimulation of dopamine D2 receptors inhibits type 1 cell [Ca2+]i response to hypoxia, consistent with an inhibitory autoreceptor role. These findings suggest dopamine-mediated inhibition and oxygen sensitivity increase with age on a similar time course and do not support a role for dopamine as a major mediator of carotid chemoreceptor resetting.

scholarly journals Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia

2010 ◽  
Vol 38 (3) ◽  
pp. 434-445 ◽  
Author(s):  
Francesco Napolitano ◽  
Massimo Pasqualetti ◽  
Alessandro Usiello ◽  
Emanuela Santini ◽  
Giulia Pacini ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Adenosine A2a Receptor ◽  
Receptor Antagonism ◽  
Dopamine D2 ◽  
Dyt1 Dystonia ◽  
A2a Receptor ◽  
Adenosine A2a

Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S646-S646
Author(s):  
Nicholas Seneca ◽  
Sjoerd Finnema ◽  
Masanori Ichise ◽  
Balazs Gulyas ◽  
Håkan Wikstrom ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Primate Brain
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