Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line – RPMI 8226

2009 ◽  
Vol 47 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Pasupuleti Sreenivasa Rao ◽  
Madduri Ramanadham ◽  
Majeti Narasimha Vara Prasad
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Myeloma Cell ◽  
Root Extract ◽  
Myeloma Cell Line ◽  
Cytotoxic Effects ◽  
Multiple Myeloma Cell ◽  
Human Multiple Myeloma ◽  
Rpmi 8226

Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter

2014 ◽  
Vol 38 (5) ◽  
pp. 563-570 ◽  
Author(s):  
Yanwei Qing ◽  
Haiyan Hu ◽  
Yuan Liu ◽  
Tao Feng ◽  
Wei Meng ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Multiple Myeloma Cell ◽  
Human Multiple Myeloma

scholarly journals Identification of a second transforming gene, rasn, in a human multiple myeloma line with a rearranged c-myc allele

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1163-1167
Author(s):  
TJ Ernst ◽  
A Gazdar ◽  
J Ritz ◽  
MA Shipp
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Focus Formation ◽  
Multiple Myeloma Cell ◽  
B Cell Malignancy ◽  
Human Multiple Myeloma ◽  
Transforming Gene

Multiple myeloma is a disease characterized by a long, slowly progressive phase and a final, more aggressive one. Little is known about the mechanism of transformation of myeloma cells, although the clinical characteristics of the disease suggest a multi-step process. Recently, a myeloma cell line, NCI-H929, was isolated from a patient with aggressive preterminal disease and found to have a rearranged myc allele. This myeloma cell line has been further characterized in a focus formation assay to determine whether its unusual growth characteristics were associated with a second activated transforming gene. We now report that the NCI-H929 myeloma cell line has an activated rasn allele in addition to a rearranged myc allele. This is the first identification of an activated transforming gene in a multiple myeloma cell line; furthermore, the characterization of two independently activated oncogenes in this B cell malignancy has implications for both the pathogenesis and evolution of the disease.

scholarly journals Identification of a second transforming gene, rasn, in a human multiple myeloma line with a rearranged c-myc allele

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1163-1167 ◽  
Author(s):  
TJ Ernst ◽  
A Gazdar ◽  
J Ritz ◽  
MA Shipp
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Focus Formation ◽  
Multiple Myeloma Cell ◽  
B Cell Malignancy ◽  
Human Multiple Myeloma ◽  
Transforming Gene

Abstract Multiple myeloma is a disease characterized by a long, slowly progressive phase and a final, more aggressive one. Little is known about the mechanism of transformation of myeloma cells, although the clinical characteristics of the disease suggest a multi-step process. Recently, a myeloma cell line, NCI-H929, was isolated from a patient with aggressive preterminal disease and found to have a rearranged myc allele. This myeloma cell line has been further characterized in a focus formation assay to determine whether its unusual growth characteristics were associated with a second activated transforming gene. We now report that the NCI-H929 myeloma cell line has an activated rasn allele in addition to a rearranged myc allele. This is the first identification of an activated transforming gene in a multiple myeloma cell line; furthermore, the characterization of two independently activated oncogenes in this B cell malignancy has implications for both the pathogenesis and evolution of the disease.

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