Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model

FEBS Letters ◽  
2006 ◽  
Vol 580 (15) ◽  
pp. 3706-3714 ◽  
Author(s):  
Yuriko Higuchi ◽  
Shigeru Kawakami ◽  
Machiko Oka ◽  
Yoshiyuki Yabe ◽  
Fumiyoshi Yamashita ◽  
...  
Keyword(s):  
Liver Failure ◽  
Intravenous Administration ◽  
Cytokine Production ◽  
Cationic Liposome ◽  
Failure Model ◽  
Murine Liver

FRI-086-Stem cell treatment on acute liver failure model using semipermeable Poly Lactic-co-Glycolic Acid membrane pouch

2019 ◽  
Vol 70 (1) ◽  
pp. e422 ◽  
Author(s):  
Bo-Kyeong Kang ◽  
Mi Mi Kim ◽  
Dae Won JUN ◽  
Jinhwa Park ◽  
Jaeyoon Jeong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Glycolic Acid ◽  
Failure Model ◽  
Stem Cell Treatment

The Significant Improvement of Survival Times and Pathological Parameters by Bioartificial Liver with Recombinant HepG2 in Porcine Liver Failure Model

2006 ◽  
Vol 15 (10) ◽  
pp. 873-880 ◽  
Author(s):  
Shin Enosawa ◽  
Tomoyuki Miyashita ◽  
Tomohiro Saito ◽  
Takeshi Omasa ◽  
Toshiharu Matsumura
Keyword(s):  
Liver Failure ◽  
Bioartificial Liver ◽  
Failure Model ◽  
Survival Times ◽  
Porcine Liver

929 GENE TRANSFER OF THE HIGH MOBILITY GROUP BOX 1 INHIBITOR IN RAT ACUTE LIVER FAILURE MODEL

2011 ◽  
Vol 54 ◽  
pp. S371-S372 ◽  
Author(s):  
M. Shinoda ◽  
M. Tanabe ◽  
A. Takayanagi ◽  
R. Nishiyama ◽  
G. Oshima ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

scholarly journals Improvement of the Survival Rate by Fetal Liver Cell Transplantation in a Mice Lethal Liver Failure Model

2007 ◽  
Vol 84 (10) ◽  
pp. 1233-1239 ◽  
Author(s):  
Takafumi Machimoto ◽  
Kentaro Yasuchika ◽  
Junji Komori ◽  
Takamichi Ishii ◽  
Naoko Kamo ◽  
...  
Keyword(s):  
Survival Rate ◽  
Liver Failure ◽  
Cell Transplantation ◽  
Liver Cell ◽  
Fetal Liver ◽  
Failure Model ◽  
Fetal Liver Cell ◽  
Liver Cell Transplantation

Gene transfer of high-mobility group box 1 box-A domain in a rat acute liver failure model

2015 ◽  
Vol 194 (2) ◽  
pp. 571-580 ◽  
Author(s):  
Masayuki Tanaka ◽  
Masahiro Shinoda ◽  
Atsushi Takayanagi ◽  
Go Oshima ◽  
Ryo Nishiyama ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
High Mobility ◽  
High Mobility Group ◽  
Failure Model

Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose

2010 ◽  
Vol 30 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Omid Mehrpour ◽  
Shahin Shadnia ◽  
Hossein Sanaei-Zadeh
Keyword(s):  
Liver Failure ◽  
Intravenous Administration ◽  
Attempted Suicide ◽  
Substantial Improvement ◽  
High Dose ◽  
Poison Center ◽  
Drug Induced ◽  
Impaired Liver ◽  
Level Of Consciousness ◽  
Liver Functions

Acetaminophen is a commonly used analgesic and has been shown to be a main cause of drug-induced liver failure. N-acetylcysteine (NAC) should be employed as the antidote in case of acetaminophen poisoning within the first 8-10 hours. Oral administration of NAC is universally recommended and due to the adverse effects, the intravenous administration of the agent is reserved for patients with oral intolerance and severe complications. We here report an 18-year-old man with severe liver failure due to a huge ingestion of acetaminophen, who was taken into the Loghman Hakim Hospital Poison Center 72 hours after attempted suicide. Regarding the poor prognostic clues as his level of consciousness and impaired liver functions, an extensive intravenous regimen of NAC was started. The patient survived the condition with an additional intravenous administration of NAC past the first 72 hours of treatment. We discuss that even in late phases of intoxication; high-dose intravenous NAC can serve a substantial improvement.

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