Early serum β-hCG values as a predictor of pregnancy viability in donor egg-in vitro fertilization cycles

The article presents a personal observation of the course of pregnancy and childbirth in a patient with a typical form of gonadal dysgenesis (ShereshevskyTurner syndrome, karyotype 45,X0/46,XY in the ratio of clones 1:1). The diagnosis was established at 12 years of age during an examination for growth retardation and lack of signs of puberty. Given the presence of a 46,XY clone in the karyotype, a high risk of malignization of dysgenetic gonads, laparoscopy and gonadectomy were performed at 12 years of age. Pregnancy occurred after preparation of the endometrium with estrogens and progestogens, as a result of the first in vitro fertilization attempt with a donor egg and her husbands sperm, occurred against the background of hormonal support with the threat of termination of pregnancy and hypercoagulation. At 34 weeks, there was a premature detachment of placenta, in connection with which she was delivered by cesarean section.

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Serum beta-subunit human chorionic gonadotropin (β-HCG) value could predict in vitro fertilization (IVF) pregnancy outcomes on the 10th day after oocytes retrieval

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.07.358 ◽

2013 ◽

Vol 100 (3) ◽

pp. S495

Author(s):

Q. Wang ◽

R. Zhang ◽

M. Jia ◽

L. Luo ◽

M. Lin ◽

...

Keyword(s):

In Vitro Fertilization ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Pregnancy Outcomes ◽

Beta Subunit ◽

Vitro Fertilization ◽

Β Hcg

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Elevated progesterone level and its consequences on IVF

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190303 ◽

2019 ◽

Vol 8 (2) ◽

pp. 672

Author(s):

Sankar Kumar Das ◽

Priyanka Roy ◽

Krishna Kalita

Keyword(s):

In Vitro Fertilization ◽

Luteinizing Hormone ◽

Oocyte Retrieval ◽

Progesterone Level ◽

Research Centre ◽

Transvaginal Sonography ◽

P Value ◽

Vitro Fertilization ◽

Β Hcg

Background: Understanding of the embryo-endometrium dialogue is still far from being understood. During conventional in vitro fertilization cycles, progesterone elevation on the day of human chorionic gonadotropin administration refers to rising progesterone levels in the absence of either premature or a luteinizing hormone surge. Most research have reported that elevated progesterone had an adverse impact on the endometrial environment of fresh cycles, leading to a decrease in pregnancy rates.Methods: The current study was undertaken at Swagat hospital and research Centre, Bongaigaon, Assam (India). Fifty patients undergoing in vitro fertilization (IVF) were selected for the study. Baseline estimation of follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH), (estrogen) E2 and (transvaginal sonography) TVS was done. The patients were grouped on the basis of their progesterone levels on the day of hCG trigger, with the cutoff for defining premature progesterone rise being (progesterone) P4≥ 3ng/ml. Final oocyte maturation was induced with hCG. Oocyte retrieval was performed 34-36 h after hCG. Two to three embryos of day 3 cleavage stage were transferred under TVS guidance. The parameters obtained from each cycle were recorded. Statistical analysis was performed. Probability (P) value <0.05 was considered statistically significant. A sonographic confirmation of pregnancy was performed 2 weeks after β-hCG positive.Results: On dividing the patients into two groups, based on the cut off of P4 as 3ng/ml, it was observed that the no of cases that conceived was significantly higher in the subjects whose P4 level was less than or equal to 3ng/ml than the subjects whose P4 level was more than 3ng/ml.Conclusions: Elevated P4 i.e. Progesterone level just before trigger is a reflection of endometrial maturity that can cause disparity between endometrial and embryonic ageing and therefore hamper implantation or cause failure in assisted reproductive technology (ART).

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