Minimal stimulation using gonadotropin-releasing hormone (GnRH) antagonist and recombinant human follicle-stimulating hormone versus GnRH antagonist multiple-dose protocol in low responders undergoing in vitro fertilization/intracytoplasmic sperm injection

2009 ◽  
Vol 92 (6) ◽  
pp. 2082-2084 ◽  
Author(s):  
Chung-Hoon Kim ◽  
So-Ra Kim ◽  
Yong-Pil Cheon ◽  
Sung-Hoon Kim ◽  
Hee-Dong Chae ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Intracytoplasmic Sperm Injection ◽  
Multiple Dose ◽  
Gnrh Antagonist ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Vitro Fertilization ◽  
Low Responders ◽  
Minimal Stimulation

scholarly journals Multiple-dose versus single-dose gonadotropin-releasing hormone agonist after first in vitro fertilization failure associated with luteal phase deficiency: A randomized controlled trial

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092602 ◽  
Author(s):  
Danni Qu ◽  
Yuan Li
Keyword(s):  
Single Dose ◽  
In Vitro Fertilization ◽  
Luteal Phase ◽  
Multiple Dose ◽  
Dose Group ◽  
Gonadotropin Releasing Hormone ◽  
Vitro Fertilization ◽  
Gonadotropin Releasing Hormone Agonist ◽  
Ivf Failure

Objective To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD). Methods Eighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second IVF attempt, patients in the single-dose group were given standard LPS plus a single dose of GnRH-a 6 days after oocyte retrieval. Patients in the multiple-dose group received standard LPS plus 14 daily injections of GnRH-a. Children conceived were followed up for 2 years. Results Pregnancy (67.5% vs. 42.5%), clinical pregnancy (50.0% vs. 22.5%), and live birth rates (42.5% vs. 20.0%) were significantly higher in the multiple-dose versus single-dose GnRH-a group. Patients in the multiple-dose GnRH-a group had significantly higher progesterone levels 14 days after oocyte recovery (35.9 vs. 21.4 ng/mL). No significant difference existed in the status at birth or developmental and behavior assessments of 2-year-old children conceived in both groups. Conclusions Daily addition of GnRH-a to standard LPS can achieve better pregnancy outcomes with a sustained safety profile in patients with a first IVF failure associated with LPD.

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